Controlling metastatic cancer: the role of phytochemicals in
cell signaling

J 2019

Controlling metastatic cancer: the role of phytochemicals in cell signaling

KAPINOVA, Andrea, Peter KUBATKA, Alena LISKOVA, Denis BARANENKO, Peter KRUŽLIAK et. al.

Basic information

Original name

Controlling metastatic cancer: the role of phytochemicals in cell signaling

Authors

KAPINOVA, Andrea (703 Slovakia), Peter KUBATKA (703 Slovakia), Alena LISKOVA (703 Slovakia), Denis BARANENKO (643 Russian Federation), Peter KRUŽLIAK (703 Slovakia, guarantor, belonging to the institution), Milan MATTA (703 Slovakia), Dietrich BUSSELBERG (634 Qatar), Bibiana MALICHEROVA (703 Slovakia), Anthony ZULLI (36 Australia), Taeg Kyu KWON (410 Republic of Korea), Eva JEZKOVA (703 Slovakia), Dana BLAHUTOVA (703 Slovakia), Pavol ZUBOR (703 Slovakia) and Jan DANKO (703 Slovakia)

Edition

Journal of cancer research and clinical oncology, Germany, Springer-Verlag, 2019, 0171-5216

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.656

RIV identification code

RIV/00216224:14110/19:00110195

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s00432-019-02892-5

UT WoS

000465605800001

Keywords in English

Metastatic cancer; Signaling pathways; Phytochemicals; Chemoprevention; Therapy

Abstract

V originále

PurposeCancer is a serious health issue and a leading cause of death worldwide. Most of the cancer patients (approximately 90%) do not die from the consequences of the primary tumor development, but due to a heavily treatable metastatic invasion. During the lengthy multistep process of carcinogenesis, there are a lot of opportunities available to reverse or slow down the tissue invasion or the process of tumor metastasis formation.ResultsCurrent research has brought many promising results from anti-metastatic experimental studies, and has shown that chemoprevention by natural or semisynthetic phytochemicals with plethora of biological activities could be one of the potentially effective options in the fight against this problem. However, there is a lack of clinical trials to confirm these findings. In this review, we focused on summarization and discussion of the general features of metastatic cancer, and recent preclinical and clinical studies dealing with anti-metastatic potential of various plant-derived compounds.ConclusionsBased on our findings, we can conclude and confirm our hypothesis that phytochemicals with pleiotropic anticancer effects can be very useful in retarding and/or reversing the metastasis process, and can also be used to prevent tissue invasion and metastases. But, further studies in this area are certainly necessary and desirable.

Citovat

KAPINOVA, Andrea, Peter KUBATKA, Alena LISKOVA, Denis BARANENKO, Peter KRUŽLIAK, Milan MATTA, Dietrich BUSSELBERG, Bibiana MALICHEROVA, Anthony ZULLI, Taeg Kyu KWON, Eva JEZKOVA, Dana BLAHUTOVA, Pavol ZUBOR and Jan DANKO. Controlling metastatic cancer: the role of phytochemicals in cell signaling. Journal of cancer research and clinical oncology. Germany: Springer-Verlag, 2019, vol. 145, No 5, p. 1087-1109. ISSN 0171-5216. Available from: https://dx.doi.org/10.1007/s00432-019-02892-5.

@article{1545976,
   author = {Kapinova, Andrea and Kubatka, Peter and Liskova, Alena and Baranenko, Denis and Kružliak, Peter and Matta, Milan and Busselberg, Dietrich and Malicherova, Bibiana and Zulli, Anthony and Kwon, Taeg Kyu and Jezkova, Eva and Blahutova, Dana and Zubor, Pavol and Danko, Jan},
   article_location = {Germany},
   article_number = {5},
   doi = {http://dx.doi.org/10.1007/s00432-019-02892-5},
   keywords = {Metastatic cancer; Signaling pathways; Phytochemicals; Chemoprevention; Therapy},
   language = {eng},
   issn = {0171-5216},
   journal = {Journal of cancer research and clinical oncology},
   title = {Controlling metastatic cancer: the role of phytochemicals in cell signaling},
   url = {http://dx.doi.org/10.1007/s00432-019-02892-5},
   volume = {145},
   year = {2019}
}

TY  - JOUR
ID  - 1545976
AU  - Kapinova, Andrea - Kubatka, Peter - Liskova, Alena - Baranenko, Denis - Kružliak, Peter - Matta, Milan - Busselberg, Dietrich - Malicherova, Bibiana - Zulli, Anthony - Kwon, Taeg Kyu - Jezkova, Eva - Blahutova, Dana - Zubor, Pavol - Danko, Jan
PY  - 2019
TI  - Controlling metastatic cancer: the role of phytochemicals in cell signaling
JF  - Journal of cancer research and clinical oncology
VL  - 145
IS  - 5
SP  - 1087-1109
EP  - 1087-1109
PB  - Springer-Verlag
SN  - 01715216
KW  - Metastatic cancer
KW  - Signaling pathways
KW  - Phytochemicals
KW  - Chemoprevention
KW  - Therapy
UR  - http://dx.doi.org/10.1007/s00432-019-02892-5
L2  - http://dx.doi.org/10.1007/s00432-019-02892-5
N2  - PurposeCancer is a serious health issue and a leading cause of death worldwide. Most of the cancer patients (approximately 90%) do not die from the consequences of the primary tumor development, but due to a heavily treatable metastatic invasion. During the lengthy multistep process of carcinogenesis, there are a lot of opportunities available to reverse or slow down the tissue invasion or the process of tumor metastasis formation.ResultsCurrent research has brought many promising results from anti-metastatic experimental studies, and has shown that chemoprevention by natural or semisynthetic phytochemicals with plethora of biological activities could be one of the potentially effective options in the fight against this problem. However, there is a lack of clinical trials to confirm these findings. In this review, we focused on summarization and discussion of the general features of metastatic cancer, and recent preclinical and clinical studies dealing with anti-metastatic potential of various plant-derived compounds.ConclusionsBased on our findings, we can conclude and confirm our hypothesis that phytochemicals with pleiotropic anticancer effects can be very useful in retarding and/or reversing the metastasis process, and can also be used to prevent tissue invasion and metastases. But, further studies in this area are certainly necessary and desirable.
ER  -

KAPINOVA, Andrea, Peter KUBATKA, Alena LISKOVA, Denis BARANENKO, Peter KRUŽLIAK, Milan MATTA, Dietrich BUSSELBERG, Bibiana MALICHEROVA, Anthony ZULLI, Taeg Kyu KWON, Eva JEZKOVA, Dana BLAHUTOVA, Pavol ZUBOR and Jan DANKO. Controlling metastatic cancer: the role of phytochemicals in cell signaling. \textit{Journal of cancer research and clinical oncology}. Germany: Springer-Verlag, 2019, vol.~145, No~5, p.~1087-1109. ISSN~0171-5216. Available from: https://dx.doi.org/10.1007/s00432-019-02892-5.

Detailed Information on Publication Record