| SAMEC, Marek, Alena LISKOVA, Peter KUBATKA, Sona URAMOVA, Pavol ZUBOR, Samson Mathews SAMUEL, Anthony ZULLI, Martin PEC, Tibor BIELIK, Kamil BIRINGER, Erik KUDELA, Jozef BENACKA, Mariusz ADAMEK, Luis RODRIGO, Rachele CICCOCIOPPO, Taeg Kyu KWON, Denis BARANENKO, Peter KRUŽLIAK a Daniel BUSSELBERG. The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression. Journal of cancer research and clinical oncology. Germany: Springer-Verlag, 2019, roč. 145, č. 7, s. 1665-1679. ISSN 0171-5216. Dostupné z: https://dx.doi.org/10.1007/s00432-019-02940-0. |
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@article{1545977,
author = {Samec, Marek and Liskova, Alena and Kubatka, Peter and Uramova, Sona and Zubor, Pavol and Samuel, Samson Mathews and Zulli, Anthony and Pec, Martin and Bielik, Tibor and Biringer, Kamil and Kudela, Erik and Benacka, Jozef and Adamek, Mariusz and Rodrigo, Luis and Ciccocioppo, Rachele and Kwon, Taeg Kyu and Baranenko, Denis and Kružliak, Peter and Busselberg, Daniel},
article_location = {Germany},
article_number = {7},
doi = {http://dx.doi.org/10.1007/s00432-019-02940-0},
keywords = {microRNAs; Phytochemicals; Plant-derived food; Cancer; Carcinogenesis},
language = {eng},
issn = {0171-5216},
journal = {Journal of cancer research and clinical oncology},
title = {The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression},
url = {http://dx.doi.org/10.1007/s00432-019-02940-0},
volume = {145},
year = {2019}
}
TY - JOUR
ID - 1545977
AU - Samec, Marek - Liskova, Alena - Kubatka, Peter - Uramova, Sona - Zubor, Pavol - Samuel, Samson Mathews - Zulli, Anthony - Pec, Martin - Bielik, Tibor - Biringer, Kamil - Kudela, Erik - Benacka, Jozef - Adamek, Mariusz - Rodrigo, Luis - Ciccocioppo, Rachele - Kwon, Taeg Kyu - Baranenko, Denis - Kružliak, Peter - Busselberg, Daniel
PY - 2019
TI - The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression
JF - Journal of cancer research and clinical oncology
VL - 145
IS - 7
SP - 1665-1679
EP - 1665-1679
PB - Springer-Verlag
SN - 01715216
KW - microRNAs
KW - Phytochemicals
KW - Plant-derived food
KW - Cancer
KW - Carcinogenesis
UR - http://dx.doi.org/10.1007/s00432-019-02940-0
L2 - http://dx.doi.org/10.1007/s00432-019-02940-0
N2 - PurposePhytochemicals are naturally occurring plant-derived compounds and some of them have the potential to serve as anticancer drugs. Based on recent evidence, aberrantly regulated expression of microRNAs (miRNAs) is closely associated with malignancy. MicroRNAs are characterized as small non-coding RNAs functioning as posttranscriptional regulators of gene expression. Accordingly, miRNAs regulate various target genes, some of which are involved in the process of carcinogenesis.ResultsThis comprehensive review emphasizes the anticancer potential of phytochemicals, either isolated or in combination, mediated by miRNAs. The ability to modulate the expression of miRNAs demonstrates their importance as regulators of tumorigenesis. Phytochemicals as anticancer agents targeting miRNAs are widely studied in preclinical in vitro and in vivo research. Unfortunately, their anticancer efficacy in targeting miRNAs is less investigated in clinical research.ConclusionsSignificant anticancer properties of phytochemicals as regulators of miRNA expression have been proven, but more studies investigating their clinical relevance are needed.
ER -
SAMEC, Marek, Alena LISKOVA, Peter KUBATKA, Sona URAMOVA, Pavol ZUBOR, Samson Mathews SAMUEL, Anthony ZULLI, Martin PEC, Tibor BIELIK, Kamil BIRINGER, Erik KUDELA, Jozef BENACKA, Mariusz ADAMEK, Luis RODRIGO, Rachele CICCOCIOPPO, Taeg Kyu KWON, Denis BARANENKO, Peter KRUŽLIAK a Daniel BUSSELBERG. The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression. \textit{Journal of cancer research and clinical oncology}. Germany: Springer-Verlag, 2019, roč.~145, č.~7, s.~1665-1679. ISSN~0171-5216. Dostupné z: https://dx.doi.org/10.1007/s00432-019-02940-0.
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