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@article{1546030,
author = {Brázdil, Milan and Doležalová, Irena and Koriťáková, Eva and Chládek, Jan and Roman, Robert and Pail, Martin and Jurak, Pavel and Shaw, Daniel Joel and Chrastina, Jan},
article_location = {LAUSANNE},
article_number = {392},
doi = {http://dx.doi.org/10.3389/fneur.2019.00392},
keywords = {vagal nerve stimulation; neurostimulation; epilepsy; efficacy prediction; EEG reactivity; epilepsy treatment},
language = {eng},
issn = {1664-2295},
journal = {FRONTIERS IN NEUROLOGY},
title = {EEG Reactivity Predicts Individual Efficacy of Vagal Nerve Stimulation in Intractable Epileptics},
url = {https://www.frontiersin.org/articles/10.3389/fneur.2019.00392/full},
volume = {10},
year = {2019}
}
TY - JOUR
ID - 1546030
AU - Brázdil, Milan - Doležalová, Irena - Koriťáková, Eva - Chládek, Jan - Roman, Robert - Pail, Martin - Jurak, Pavel - Shaw, Daniel Joel - Chrastina, Jan
PY - 2019
TI - EEG Reactivity Predicts Individual Efficacy of Vagal Nerve Stimulation in Intractable Epileptics
JF - FRONTIERS IN NEUROLOGY
VL - 10
IS - 392
SP - 1-11
EP - 1-11
PB - FRONTIERS MEDIA SA
SN - 16642295
KW - vagal nerve stimulation
KW - neurostimulation
KW - epilepsy
KW - efficacy prediction
KW - EEG reactivity
KW - epilepsy treatment
UR - https://www.frontiersin.org/articles/10.3389/fneur.2019.00392/full
L2 - https://www.frontiersin.org/articles/10.3389/fneur.2019.00392/full
N2 - Background: Chronic vagal nerve stimulation (VNS) is a well-established non-pharmacological treatment option for drug-resistant epilepsy. This study sought to develop a statistical model for prediction of VNS efficacy. We hypothesized that reactivity of the electroencephalogram (EEG) to external stimuli measured during routine preoperative evaluation differs between VNS responders and non-responders. Materials and Methods: Power spectral analyses were computed retrospectively on pre-operative EEG recordings from 60 epileptic patients with VNS. Thirty five responders and 25 non-responders were compared on the relative power values in four standard frequency bands and eight conditions of clinical assessment-eyes opening/closing, photic stimulation, and hyperventilation. Using logistic regression, groups of electrodes within anatomical areas identified as maximally discriminative by n leave-one-out iterations were used to classify patients. The reliability of the predictive model was verified with an independent data-set from 22 additional patients. Results: Power spectral analyses revealed significant differences in EEG reactivity between responders and non-responders; specifically, the dynamics of alpha and gamma activity strongly reflected VNS efficacy. Using individual EEG reactivity to develop and validate a predictive model, we discriminated between responders and non-responders with 86% accuracy, 83% sensitivity, and 90% specificity. Conclusion: We present a new statistical model with which EEG reactivity to external stimuli during routine presurgical evaluation can be seen as a promising avenue for the identification of patients with favorable VNS outcome. This novel method for the prediction of VNS efficacy might represent a breakthrough in the management of drug-resistant epilepsy, with wide-reaching medical and economic implications.
ER -
BRÁZDIL, Milan, Irena DOLEŽALOVÁ, Eva KORIŤÁKOVÁ, Jan CHLÁDEK, Robert ROMAN, Martin PAIL, Pavel JURAK, Daniel Joel SHAW and Jan CHRASTINA. EEG Reactivity Predicts Individual Efficacy of Vagal Nerve Stimulation in Intractable Epileptics. \textit{FRONTIERS IN NEUROLOGY}. LAUSANNE: FRONTIERS MEDIA SA, 2019, vol.~10, No~392, p.~1-11. ISSN~1664-2295. Available from: https://dx.doi.org/10.3389/fneur.2019.00392.
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