Hydrogen Sulfide as a Toxic Product in the Small–Large
Intestine Axis and its Role in IBD Development

J 2019

Hydrogen Sulfide as a Toxic Product in the Small–Large Intestine Axis and its Role in IBD Development

KUSHKEVYCH, Ivan; Dani DORDEVIĆ; Peter KOLLÁR; Monika VÍTĚZOVÁ; Lorenzo DRAGO et. al.

Základní údaje

Originální název

Hydrogen Sulfide as a Toxic Product in the Small–Large Intestine Axis and its Role in IBD Development

Autoři

KUSHKEVYCH, Ivan (804 Ukrajina, garant, domácí); Dani DORDEVIĆ (203 Česká republika); Peter KOLLÁR (203 Česká republika); Monika VÍTĚZOVÁ (203 Česká republika, domácí) a Lorenzo DRAGO (380 Itálie)

Vydání

Journal of Clinical Medicine, BASEL, MDPI, 2019, 2077-0383

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.303

Kód RIV

RIV/00216224:14310/19:00110221

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.3390/jcm8071054

UT WoS

000479003300137

EID Scopus

2-s2.0-85075345639

Klíčová slova anglicky

small–large intestine axis; hydrogen sulfide; Desulfovibrio; bowel disease; colitis

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 3. 2020 13:13, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

The small–large intestine axis in hydrogen sulfide accumulation and testing of sulfate and lactate in the gut–gut axis of the intestinal environment has not been well described. Sulfate reducing bacteria (SRB) of the Desulfovibrio genus reduce sulfate to hydrogen sulfide and can be involved in ulcerative colitis development. The background of the research was to find correlations between hydrogen sulfide production under the effect of an electron acceptor (sulfate) and donor (lactate) at different concentrations and Desulfovibrio piger Vib-7 growth, as well as their dissimilatory sulfate reduction in the intestinal small–large intestinal environment. Methods: Microbiological, biochemical, and biophysical methods, and statistical processing of the results (principal component and cross-correlation analyses) were used. Results: D. piger Vib-7 showed increased intensity of bacterial growth and hydrogen sulfide production under the following concentrations of sulfate and lactate: 17.4 mM and 35.6 mM, respectively. The study showed in what kind of intestinal environment D. piger Vib-7 grows at the highest level and produces the highest amount of hydrogen sulfide. Conclusions: The optimum intestinal environment of D. piger Vib-7 can serve as a good indicator of the occurrence of inflammatory bowel diseases; meaning that these findings can be broadly used in medicine practice dealing with the monitoring and diagnosis of intestinal ailments.

Návaznosti

MUNI/A/0902/2018, interní kód MU

Název: Podpora výzkumné činnosti studentů Mikrobiologie a molekulární biotechnologie 3

Investor: Masarykova univerzita, Podpora výzkumné činnosti studentů Mikrobiologie a molekulární biotechnologie 3, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

KUSHKEVYCH, Ivan; Dani DORDEVIĆ; Peter KOLLÁR; Monika VÍTĚZOVÁ a Lorenzo DRAGO. Hydrogen Sulfide as a Toxic Product in the Small–Large Intestine Axis and its Role in IBD Development. Journal of Clinical Medicine. BASEL: MDPI, 2019, roč. 8, č. 7, s. 1-11. ISSN 2077-0383. Dostupné z: https://dx.doi.org/10.3390/jcm8071054.

@article{1546420,
   author = {Kushkevych, Ivan and Dordević, Dani and Kollár, Peter and Vítězová, Monika and Drago, Lorenzo},
   article_location = {BASEL},
   article_number = {7},
   doi = {http://dx.doi.org/10.3390/jcm8071054},
   keywords = {small–large intestine axis; hydrogen sulfide; Desulfovibrio; bowel disease; colitis},
   language = {eng},
   issn = {2077-0383},
   journal = {Journal of Clinical Medicine},
   title = {Hydrogen Sulfide as a Toxic Product in the Small–Large Intestine Axis and its Role in IBD Development},
   url = {https://www.mdpi.com/2077-0383/8/7/1054},
   volume = {8},
   year = {2019}
}

TY  - JOUR
ID  - 1546420
AU  - Kushkevych, Ivan - Dordević, Dani - Kollár, Peter - Vítězová, Monika - Drago, Lorenzo
PY  - 2019
TI  - Hydrogen Sulfide as a Toxic Product in the Small–Large Intestine Axis and its Role in IBD Development
JF  - Journal of Clinical Medicine
VL  - 8
IS  - 7
SP  - 1-11
EP  - 1-11
PB  - MDPI
SN  - 20770383
KW  - small–large intestine axis
KW  - hydrogen sulfide
KW  - Desulfovibrio
KW  - bowel disease
KW  - colitis
UR  - https://www.mdpi.com/2077-0383/8/7/1054
L2  - https://www.mdpi.com/2077-0383/8/7/1054
N2  - The small–large intestine axis in hydrogen sulfide accumulation and testing of sulfate and lactate in the gut–gut axis of the intestinal environment has not been well described. Sulfate reducing bacteria (SRB) of the Desulfovibrio genus reduce sulfate to hydrogen sulfide and can be involved in ulcerative colitis development. The background of the research was to find correlations between hydrogen sulfide production under the effect of an electron acceptor (sulfate) and donor (lactate) at different concentrations and Desulfovibrio piger Vib-7 growth, as well as their dissimilatory sulfate reduction in the intestinal small–large intestinal environment. Methods: Microbiological, biochemical, and biophysical methods, and statistical processing of the results (principal component and cross-correlation analyses) were used. Results: D. piger Vib-7 showed increased intensity of bacterial growth and hydrogen sulfide production under the following concentrations of sulfate and lactate: 17.4 mM and 35.6 mM, respectively. The study showed in what kind of intestinal environment D. piger Vib-7 grows at the highest level and produces the highest amount of hydrogen sulfide. Conclusions: The optimum intestinal environment of D. piger Vib-7 can serve as a good indicator of the occurrence of inflammatory bowel diseases; meaning that these findings can be broadly used in medicine practice dealing with the monitoring and diagnosis of intestinal ailments.
ER  -

KUSHKEVYCH, Ivan; Dani DORDEVI$\backslash$'C; Peter KOLLÁR; Monika VÍTĚZOVÁ a Lorenzo DRAGO. Hydrogen Sulfide as a Toxic Product in the Small–Large Intestine Axis and its Role in IBD Development. \textit{Journal of Clinical Medicine}. BASEL: MDPI, 2019, roč.~8, č.~7, s.~1-11. ISSN~2077-0383. Dostupné z: https://dx.doi.org/10.3390/jcm8071054.

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