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@article{1548477, author = {Mikeš, Ondřej and Vrbová, Markéta and Klánová, Jana and Čupr, Pavel and Švancara, Jan and Pikhart, Hynek}, article_location = {Amsterdam}, article_number = {May}, doi = {http://dx.doi.org/10.1016/j.scitotenv.2019.01.254}, keywords = {Wheezing; Household chemicals; Asthma; ELSPAC; Cohort; Children; Indoor}, language = {eng}, issn = {0048-9697}, journal = {Science of the Total Environment}, title = {Early-life exposure to household chemicals and wheezing in children}, url = {https://www.sciencedirect.com/science/article/pii/S0048969719302438?via%3Dihub}, volume = {663}, year = {2019} }
TY - JOUR ID - 1548477 AU - Mikeš, Ondřej - Vrbová, Markéta - Klánová, Jana - Čupr, Pavel - Švancara, Jan - Pikhart, Hynek PY - 2019 TI - Early-life exposure to household chemicals and wheezing in children JF - Science of the Total Environment VL - 663 IS - May SP - 418-425 EP - 418-425 PB - Elsevier Science SN - 00489697 KW - Wheezing KW - Household chemicals KW - Asthma KW - ELSPAC KW - Cohort KW - Children KW - Indoor UR - https://www.sciencedirect.com/science/article/pii/S0048969719302438?via%3Dihub L2 - https://www.sciencedirect.com/science/article/pii/S0048969719302438?via%3Dihub N2 - The prevalence of the asthmatic symptoms among children increases globally over the time. Reduced exposure to pathogens in early childhood and increased exposure to anthropogenic irritants result in increased risk of wheezing in children, and all of this may be related to the usage of household chemicals. Objective of this analysis thus was to study the potential effects of overall exposure to home chemicals in the early life on the phenotypes of wheezing from birth until five years of age. 3411 mother-infant pairs from the Czech part of the European Longitudinal Study of Pregnancy and Childhood (ELSPAC-CZ) participated in the study. The exposure was estimated by the composite household chemical score from 18 chemical-based products. Social, medical and environmental factors were taken into account as covariates in multivariable multinomial logistic regression using phenotypes of wheezing as a study outcome. We were able to determine the association between several wheezing childhood phenotypes and the frequent usage of household chemicals in the fully adjusted model. Statistically significant odds ratios (OR) for increasing exposures per 1 SD of exposure score were obtained for the intermediate onset transient (OR 1.27, 95% CI 1.10-1.47), intermediated onset persistent (OR 1.23, 95% CI 1.03-1.46), and early onset persistent phenotypes (OR 1.36, 95% CI 1.04-1.77) in comparison to never wheezing children. Moreover, the persistent phenotypes were significantly associated with school age asthma. Our study negative role of the increased household chemicals usage on the respiratory outcomes in children up to five years of age. Overall evaluation of the household chemical exposure may be useful tool for any large epidemiological studies. ER -
MIKEŠ, Ondřej, Markéta VRBOVÁ, Jana KLÁNOVÁ, Pavel ČUPR, Jan ŠVANCARA and Hynek PIKHART. Early-life exposure to household chemicals and wheezing in children. \textit{Science of the Total Environment}. Amsterdam: Elsevier Science, 2019, vol.~663, May, p.~418-425. ISSN~0048-9697. Available from: https://dx.doi.org/10.1016/j.scitotenv.2019.01.254.
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