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@article{1548477,
author = {Mikeš, Ondřej and Vrbová, Markéta and Klánová, Jana and Čupr, Pavel and Švancara, Jan and Pikhart, Hynek},
article_location = {Amsterdam},
article_number = {May},
doi = {http://dx.doi.org/10.1016/j.scitotenv.2019.01.254},
keywords = {Wheezing; Household chemicals; Asthma; ELSPAC; Cohort; Children; Indoor},
language = {eng},
issn = {0048-9697},
journal = {Science of the Total Environment},
title = {Early-life exposure to household chemicals and wheezing in children},
url = {https://www.sciencedirect.com/science/article/pii/S0048969719302438?via%3Dihub},
volume = {663},
year = {2019}
}
TY - JOUR
ID - 1548477
AU - Mikeš, Ondřej - Vrbová, Markéta - Klánová, Jana - Čupr, Pavel - Švancara, Jan - Pikhart, Hynek
PY - 2019
TI - Early-life exposure to household chemicals and wheezing in children
JF - Science of the Total Environment
VL - 663
IS - May
SP - 418-425
EP - 418-425
PB - Elsevier Science
SN - 00489697
KW - Wheezing
KW - Household chemicals
KW - Asthma
KW - ELSPAC
KW - Cohort
KW - Children
KW - Indoor
UR - https://www.sciencedirect.com/science/article/pii/S0048969719302438?via%3Dihub
L2 - https://www.sciencedirect.com/science/article/pii/S0048969719302438?via%3Dihub
N2 - The prevalence of the asthmatic symptoms among children increases globally over the time. Reduced exposure to pathogens in early childhood and increased exposure to anthropogenic irritants result in increased risk of wheezing in children, and all of this may be related to the usage of household chemicals. Objective of this analysis thus was to study the potential effects of overall exposure to home chemicals in the early life on the phenotypes of wheezing from birth until five years of age. 3411 mother-infant pairs from the Czech part of the European Longitudinal Study of Pregnancy and Childhood (ELSPAC-CZ) participated in the study. The exposure was estimated by the composite household chemical score from 18 chemical-based products. Social, medical and environmental factors were taken into account as covariates in multivariable multinomial logistic regression using phenotypes of wheezing as a study outcome. We were able to determine the association between several wheezing childhood phenotypes and the frequent usage of household chemicals in the fully adjusted model. Statistically significant odds ratios (OR) for increasing exposures per 1 SD of exposure score were obtained for the intermediate onset transient (OR 1.27, 95% CI 1.10-1.47), intermediated onset persistent (OR 1.23, 95% CI 1.03-1.46), and early onset persistent phenotypes (OR 1.36, 95% CI 1.04-1.77) in comparison to never wheezing children. Moreover, the persistent phenotypes were significantly associated with school age asthma. Our study negative role of the increased household chemicals usage on the respiratory outcomes in children up to five years of age. Overall evaluation of the household chemical exposure may be useful tool for any large epidemiological studies.
ER -
MIKEŠ, Ondřej, Markéta VRBOVÁ, Jana KLÁNOVÁ, Pavel ČUPR, Jan ŠVANCARA and Hynek PIKHART. Early-life exposure to household chemicals and wheezing in children. \textit{Science of the Total Environment}. Amsterdam: Elsevier Science, 2019, vol.~663, May, p.~418-425. ISSN~0048-9697. Available from: https://dx.doi.org/10.1016/j.scitotenv.2019.01.254.
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