Early-life exposure to household chemicals and wheezing in
children

J 2019

Early-life exposure to household chemicals and wheezing in children

MIKEŠ, Ondřej, Markéta VRBOVÁ, Jana KLÁNOVÁ, Pavel ČUPR, Jan ŠVANCARA et. al.

Basic information

Original name

Early-life exposure to household chemicals and wheezing in children

Authors

MIKEŠ, Ondřej (203 Czech Republic, belonging to the institution), Markéta VRBOVÁ (203 Czech Republic, belonging to the institution), Jana KLÁNOVÁ (203 Czech Republic, belonging to the institution), Pavel ČUPR (203 Czech Republic, belonging to the institution), Jan ŠVANCARA (203 Czech Republic, belonging to the institution) and Hynek PIKHART (203 Czech Republic, guarantor, belonging to the institution)

Edition

Science of the Total Environment, Amsterdam, Elsevier Science, 2019, 0048-9697

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10511 Environmental sciences

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 6.551

RIV identification code

RIV/00216224:14310/19:00110312

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.scitotenv.2019.01.254

UT WoS

000459858500041

Keywords in English

Wheezing; Household chemicals; Asthma; ELSPAC; Cohort; Children; Indoor

Abstract

V originále

The prevalence of the asthmatic symptoms among children increases globally over the time. Reduced exposure to pathogens in early childhood and increased exposure to anthropogenic irritants result in increased risk of wheezing in children, and all of this may be related to the usage of household chemicals. Objective of this analysis thus was to study the potential effects of overall exposure to home chemicals in the early life on the phenotypes of wheezing from birth until five years of age. 3411 mother-infant pairs from the Czech part of the European Longitudinal Study of Pregnancy and Childhood (ELSPAC-CZ) participated in the study. The exposure was estimated by the composite household chemical score from 18 chemical-based products. Social, medical and environmental factors were taken into account as covariates in multivariable multinomial logistic regression using phenotypes of wheezing as a study outcome. We were able to determine the association between several wheezing childhood phenotypes and the frequent usage of household chemicals in the fully adjusted model. Statistically significant odds ratios (OR) for increasing exposures per 1 SD of exposure score were obtained for the intermediate onset transient (OR 1.27, 95% CI 1.10-1.47), intermediated onset persistent (OR 1.23, 95% CI 1.03-1.46), and early onset persistent phenotypes (OR 1.36, 95% CI 1.04-1.77) in comparison to never wheezing children. Moreover, the persistent phenotypes were significantly associated with school age asthma. Our study negative role of the increased household chemicals usage on the respiratory outcomes in children up to five years of age. Overall evaluation of the household chemical exposure may be useful tool for any large epidemiological studies.

Links

EF15_003/0000469, research and development project

Name: Cetocoen Plus

EF16_013/0001761, research and development project

Name: RECETOX RI

LM2015051, research and development project

Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

MIKEŠ, Ondřej, Markéta VRBOVÁ, Jana KLÁNOVÁ, Pavel ČUPR, Jan ŠVANCARA and Hynek PIKHART. Early-life exposure to household chemicals and wheezing in children. Science of the Total Environment. Amsterdam: Elsevier Science, 2019, vol. 663, May, p. 418-425. ISSN 0048-9697. Available from: https://dx.doi.org/10.1016/j.scitotenv.2019.01.254.

@article{1548477,
   author = {Mikeš, Ondřej and Vrbová, Markéta and Klánová, Jana and Čupr, Pavel and Švancara, Jan and Pikhart, Hynek},
   article_location = {Amsterdam},
   article_number = {May},
   doi = {http://dx.doi.org/10.1016/j.scitotenv.2019.01.254},
   keywords = {Wheezing; Household chemicals; Asthma; ELSPAC; Cohort; Children; Indoor},
   language = {eng},
   issn = {0048-9697},
   journal = {Science of the Total Environment},
   title = {Early-life exposure to household chemicals and wheezing in children},
   url = {https://www.sciencedirect.com/science/article/pii/S0048969719302438?via%3Dihub},
   volume = {663},
   year = {2019}
}

TY  - JOUR
ID  - 1548477
AU  - Mikeš, Ondřej - Vrbová, Markéta - Klánová, Jana - Čupr, Pavel - Švancara, Jan - Pikhart, Hynek
PY  - 2019
TI  - Early-life exposure to household chemicals and wheezing in children
JF  - Science of the Total Environment
VL  - 663
IS  - May
SP  - 418-425
EP  - 418-425
PB  - Elsevier Science
SN  - 00489697
KW  - Wheezing
KW  - Household chemicals
KW  - Asthma
KW  - ELSPAC
KW  - Cohort
KW  - Children
KW  - Indoor
UR  - https://www.sciencedirect.com/science/article/pii/S0048969719302438?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S0048969719302438?via%3Dihub
N2  - The prevalence of the asthmatic symptoms among children increases globally over the time. Reduced exposure to pathogens in early childhood and increased exposure to anthropogenic irritants result in increased risk of wheezing in children, and all of this may be related to the usage of household chemicals. Objective of this analysis thus was to study the potential effects of overall exposure to home chemicals in the early life on the phenotypes of wheezing from birth until five years of age. 3411 mother-infant pairs from the Czech part of the European Longitudinal Study of Pregnancy and Childhood (ELSPAC-CZ) participated in the study. The exposure was estimated by the composite household chemical score from 18 chemical-based products. Social, medical and environmental factors were taken into account as covariates in multivariable multinomial logistic regression using phenotypes of wheezing as a study outcome. We were able to determine the association between several wheezing childhood phenotypes and the frequent usage of household chemicals in the fully adjusted model. Statistically significant odds ratios (OR) for increasing exposures per 1 SD of exposure score were obtained for the intermediate onset transient (OR 1.27, 95% CI 1.10-1.47), intermediated onset persistent (OR 1.23, 95% CI 1.03-1.46), and early onset persistent phenotypes (OR 1.36, 95% CI 1.04-1.77) in comparison to never wheezing children. Moreover, the persistent phenotypes were significantly associated with school age asthma. Our study negative role of the increased household chemicals usage on the respiratory outcomes in children up to five years of age. Overall evaluation of the household chemical exposure may be useful tool for any large epidemiological studies.
ER  -

MIKEŠ, Ondřej, Markéta VRBOVÁ, Jana KLÁNOVÁ, Pavel ČUPR, Jan ŠVANCARA and Hynek PIKHART. Early-life exposure to household chemicals and wheezing in children. \textit{Science of the Total Environment}. Amsterdam: Elsevier Science, 2019, vol.~663, May, p.~418-425. ISSN~0048-9697. Available from: https://dx.doi.org/10.1016/j.scitotenv.2019.01.254.

Detailed Information on Publication Record