| VALKENIER, Hennie, Omer Adeeb Hussein AKRAWI, Pia Yasmine JURČEK, Kristína SLEZIAKOVÁ, Tomáš LÍZAL, Kristin BARTIK and Vladimír ŠINDELÁŘ. Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters. CHEM. CAMBRIDGE: CELL PRESS, 2019, vol. 5, No 2, p. 429-444. ISSN 2451-9294. Available from: https://dx.doi.org/10.1016/j.chempr.2018.11.008. |
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@article{1548759,
author = {Valkenier, Hennie and Akrawi, Omer Adeeb Hussein and Jurček, Pia Yasmine and Sleziaková, Kristína and Lízal, Tomáš and Bartik, Kristin and Šindelář, Vladimír},
article_location = {CAMBRIDGE},
article_number = {2},
doi = {http://dx.doi.org/10.1016/j.chempr.2018.11.008},
keywords = {ANION TRANSPORT; MEDIATED TRANSPORT; CHLORIDE TRANSPORT; HIGH-AFFINITY; BICARBONATE; MEMBRANE; BINDING; POWERFUL; NITRATE; MACROCYCLE},
language = {eng},
issn = {2451-9294},
journal = {CHEM},
title = {Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters},
url = {https://www.sciencedirect.com/science/article/abs/pii/S2451929418305254?via%3Dihub},
volume = {5},
year = {2019}
}
TY - JOUR
ID - 1548759
AU - Valkenier, Hennie - Akrawi, Omer Adeeb Hussein - Jurček, Pia Yasmine - Sleziaková, Kristína - Lízal, Tomáš - Bartik, Kristin - Šindelář, Vladimír
PY - 2019
TI - Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters
JF - CHEM
VL - 5
IS - 2
SP - 429-444
EP - 429-444
PB - CELL PRESS
SN - 24519294
KW - ANION TRANSPORT
KW - MEDIATED TRANSPORT
KW - CHLORIDE TRANSPORT
KW - HIGH-AFFINITY
KW - BICARBONATE
KW - MEMBRANE
KW - BINDING
KW - POWERFUL
KW - NITRATE
KW - MACROCYCLE
UR - https://www.sciencedirect.com/science/article/abs/pii/S2451929418305254?via%3Dihub
L2 - https://www.sciencedirect.com/science/article/abs/pii/S2451929418305254?via%3Dihub
N2 - The exchange of chloride and bicarbonate across lipid bilayers is an important biological process. Synthetic molecules can act as mobile carriers for these anions, although most show little selectivity. Here we report on three bambus[6] uril macrocycles functionalized with fluorinated benzyl groups, which are able to exchange Cl- and HCO3- efficiently. Remarkably, rates for Cl-/NO3- exchange are two orders of magnitude lower. The higher rates of a Cl-/HCO3- transport can be explained by the ability of the bambusurils to complex Cl- and HCO3- simultaneously, facilitating their exchange at the bilayer interface. Furthermore, the exceptionally high affinity and selectivity of these systems for NO3- appear to contribute to the poor Cl-/NO3- exchange. This work not only demonstrates the importance of anion binding characteristics on anion transport but also the potential relevance of bambusurils for anion transport applications considering the high rate observed for Cl-/HCO3- exchange.
ER -
VALKENIER, Hennie, Omer Adeeb Hussein AKRAWI, Pia Yasmine JURČEK, Kristína SLEZIAKOVÁ, Tomáš LÍZAL, Kristin BARTIK and Vladimír ŠINDELÁŘ. Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters. \textit{CHEM}. CAMBRIDGE: CELL PRESS, 2019, vol.~5, No~2, p.~429-444. ISSN~2451-9294. Available from: https://dx.doi.org/10.1016/j.chempr.2018.11.008.
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