Fluorinated Bambusurils as Highly Effective and Selective
Transmembrane Cl-/HCO3- Antiporters

J 2019

Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters

VALKENIER, Hennie, Omer Adeeb Hussein AKRAWI, Pia Yasmine JURČEK, Kristína SLEZIAKOVÁ, Tomáš LÍZAL et. al.

Basic information

Original name

Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters

Authors

VALKENIER, Hennie (56 Belgium), Omer Adeeb Hussein AKRAWI (368 Iraq, belonging to the institution), Pia Yasmine JURČEK (246 Finland, belonging to the institution), Kristína SLEZIAKOVÁ (703 Slovakia, belonging to the institution), Tomáš LÍZAL (203 Czech Republic, belonging to the institution), Kristin BARTIK (56 Belgium) and Vladimír ŠINDELÁŘ (203 Czech Republic, guarantor, belonging to the institution)

Edition

CHEM, CAMBRIDGE, CELL PRESS, 2019, 2451-9294

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10400 1.4 Chemical sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Full Text

Impact factor

Impact factor: 19.735

RIV identification code

RIV/00216224:14310/19:00107547

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.chempr.2018.11.008

UT WoS

000458660100016

Keywords in English

ANION TRANSPORT; MEDIATED TRANSPORT; CHLORIDE TRANSPORT; HIGH-AFFINITY; BICARBONATE; MEMBRANE; BINDING; POWERFUL; NITRATE; MACROCYCLE

Abstract

V originále

The exchange of chloride and bicarbonate across lipid bilayers is an important biological process. Synthetic molecules can act as mobile carriers for these anions, although most show little selectivity. Here we report on three bambus[6] uril macrocycles functionalized with fluorinated benzyl groups, which are able to exchange Cl- and HCO3- efficiently. Remarkably, rates for Cl-/NO3- exchange are two orders of magnitude lower. The higher rates of a Cl-/HCO3- transport can be explained by the ability of the bambusurils to complex Cl- and HCO3- simultaneously, facilitating their exchange at the bilayer interface. Furthermore, the exceptionally high affinity and selectivity of these systems for NO3- appear to contribute to the poor Cl-/NO3- exchange. This work not only demonstrates the importance of anion binding characteristics on anion transport but also the potential relevance of bambusurils for anion transport applications considering the high rate observed for Cl-/HCO3- exchange.

Links

EF16_013/0001761, research and development project

Name: RECETOX RI

GA18-21801S, research and development project

Name: Chirální bambusurily

Investor: Czech Science Foundation

LM2015043, research and development project

Name: Česká infrastruktura pro integrativní strukturní biologii (Acronym: CIISB)

Investor: Ministry of Education, Youth and Sports of the CR

LM2015051, research and development project

Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

VALKENIER, Hennie, Omer Adeeb Hussein AKRAWI, Pia Yasmine JURČEK, Kristína SLEZIAKOVÁ, Tomáš LÍZAL, Kristin BARTIK and Vladimír ŠINDELÁŘ. Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters. CHEM. CAMBRIDGE: CELL PRESS, 2019, vol. 5, No 2, p. 429-444. ISSN 2451-9294. Available from: https://dx.doi.org/10.1016/j.chempr.2018.11.008.

@article{1548759,
   author = {Valkenier, Hennie and Akrawi, Omer Adeeb Hussein and Jurček, Pia Yasmine and Sleziaková, Kristína and Lízal, Tomáš and Bartik, Kristin and Šindelář, Vladimír},
   article_location = {CAMBRIDGE},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.chempr.2018.11.008},
   keywords = {ANION TRANSPORT; MEDIATED TRANSPORT; CHLORIDE TRANSPORT; HIGH-AFFINITY; BICARBONATE; MEMBRANE; BINDING; POWERFUL; NITRATE; MACROCYCLE},
   language = {eng},
   issn = {2451-9294},
   journal = {CHEM},
   title = {Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters},
   url = {https://www.sciencedirect.com/science/article/abs/pii/S2451929418305254?via%3Dihub},
   volume = {5},
   year = {2019}
}

TY  - JOUR
ID  - 1548759
AU  - Valkenier, Hennie - Akrawi, Omer Adeeb Hussein - Jurček, Pia Yasmine - Sleziaková, Kristína - Lízal, Tomáš - Bartik, Kristin - Šindelář, Vladimír
PY  - 2019
TI  - Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters
JF  - CHEM
VL  - 5
IS  - 2
SP  - 429-444
EP  - 429-444
PB  - CELL PRESS
SN  - 24519294
KW  - ANION TRANSPORT
KW  - MEDIATED TRANSPORT
KW  - CHLORIDE TRANSPORT
KW  - HIGH-AFFINITY
KW  - BICARBONATE
KW  - MEMBRANE
KW  - BINDING
KW  - POWERFUL
KW  - NITRATE
KW  - MACROCYCLE
UR  - https://www.sciencedirect.com/science/article/abs/pii/S2451929418305254?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/abs/pii/S2451929418305254?via%3Dihub
N2  - The exchange of chloride and bicarbonate across lipid bilayers is an important biological process. Synthetic molecules can act as mobile carriers for these anions, although most show little selectivity. Here we report on three bambus[6] uril macrocycles functionalized with fluorinated benzyl groups, which are able to exchange Cl- and HCO3- efficiently. Remarkably, rates for Cl-/NO3- exchange are two orders of magnitude lower. The higher rates of a Cl-/HCO3- transport can be explained by the ability of the bambusurils to complex Cl- and HCO3- simultaneously, facilitating their exchange at the bilayer interface. Furthermore, the exceptionally high affinity and selectivity of these systems for NO3- appear to contribute to the poor Cl-/NO3- exchange. This work not only demonstrates the importance of anion binding characteristics on anion transport but also the potential relevance of bambusurils for anion transport applications considering the high rate observed for Cl-/HCO3- exchange.
ER  -

VALKENIER, Hennie, Omer Adeeb Hussein AKRAWI, Pia Yasmine JURČEK, Kristína SLEZIAKOVÁ, Tomáš LÍZAL, Kristin BARTIK and Vladimír ŠINDELÁŘ. Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters. \textit{CHEM}. CAMBRIDGE: CELL PRESS, 2019, vol.~5, No~2, p.~429-444. ISSN~2451-9294. Available from: https://dx.doi.org/10.1016/j.chempr.2018.11.008.

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