VALKENIER, Hennie, Omer Adeeb Hussein AKRAWI, Pia Yasmine JURČEK, Kristína SLEZIAKOVÁ, Tomáš LÍZAL, Kristin BARTIK and Vladimír ŠINDELÁŘ. Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters. CHEM. CAMBRIDGE: CELL PRESS, 2019, vol. 5, No 2, p. 429-444. ISSN 2451-9294. Available from: https://dx.doi.org/10.1016/j.chempr.2018.11.008. |
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@article{1548759, author = {Valkenier, Hennie and Akrawi, Omer Adeeb Hussein and Jurček, Pia Yasmine and Sleziaková, Kristína and Lízal, Tomáš and Bartik, Kristin and Šindelář, Vladimír}, article_location = {CAMBRIDGE}, article_number = {2}, doi = {http://dx.doi.org/10.1016/j.chempr.2018.11.008}, keywords = {ANION TRANSPORT; MEDIATED TRANSPORT; CHLORIDE TRANSPORT; HIGH-AFFINITY; BICARBONATE; MEMBRANE; BINDING; POWERFUL; NITRATE; MACROCYCLE}, language = {eng}, issn = {2451-9294}, journal = {CHEM}, title = {Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters}, url = {https://www.sciencedirect.com/science/article/abs/pii/S2451929418305254?via%3Dihub}, volume = {5}, year = {2019} }
TY - JOUR ID - 1548759 AU - Valkenier, Hennie - Akrawi, Omer Adeeb Hussein - Jurček, Pia Yasmine - Sleziaková, Kristína - Lízal, Tomáš - Bartik, Kristin - Šindelář, Vladimír PY - 2019 TI - Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters JF - CHEM VL - 5 IS - 2 SP - 429-444 EP - 429-444 PB - CELL PRESS SN - 24519294 KW - ANION TRANSPORT KW - MEDIATED TRANSPORT KW - CHLORIDE TRANSPORT KW - HIGH-AFFINITY KW - BICARBONATE KW - MEMBRANE KW - BINDING KW - POWERFUL KW - NITRATE KW - MACROCYCLE UR - https://www.sciencedirect.com/science/article/abs/pii/S2451929418305254?via%3Dihub L2 - https://www.sciencedirect.com/science/article/abs/pii/S2451929418305254?via%3Dihub N2 - The exchange of chloride and bicarbonate across lipid bilayers is an important biological process. Synthetic molecules can act as mobile carriers for these anions, although most show little selectivity. Here we report on three bambus[6] uril macrocycles functionalized with fluorinated benzyl groups, which are able to exchange Cl- and HCO3- efficiently. Remarkably, rates for Cl-/NO3- exchange are two orders of magnitude lower. The higher rates of a Cl-/HCO3- transport can be explained by the ability of the bambusurils to complex Cl- and HCO3- simultaneously, facilitating their exchange at the bilayer interface. Furthermore, the exceptionally high affinity and selectivity of these systems for NO3- appear to contribute to the poor Cl-/NO3- exchange. This work not only demonstrates the importance of anion binding characteristics on anion transport but also the potential relevance of bambusurils for anion transport applications considering the high rate observed for Cl-/HCO3- exchange. ER -
VALKENIER, Hennie, Omer Adeeb Hussein AKRAWI, Pia Yasmine JURČEK, Kristína SLEZIAKOVÁ, Tomáš LÍZAL, Kristin BARTIK and Vladimír ŠINDELÁŘ. Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters. \textit{CHEM}. CAMBRIDGE: CELL PRESS, 2019, vol.~5, No~2, p.~429-444. ISSN~2451-9294. Available from: https://dx.doi.org/10.1016/j.chempr.2018.11.008.
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