Detailed Information on Publication Record
2019
Prioritization of hazards of novel flame retardants using the mechanistic toxicology information from ToxCast and Adverse Outcome Pathways
BAJARD ÉP.ESNER, Lola Murielle, Lisa Emily MELYMUK and Luděk BLÁHABasic information
Original name
Prioritization of hazards of novel flame retardants using the mechanistic toxicology information from ToxCast and Adverse Outcome Pathways
Authors
BAJARD ÉP.ESNER, Lola Murielle (250 France, belonging to the institution), Lisa Emily MELYMUK (124 Canada, belonging to the institution) and Luděk BLÁHA (203 Czech Republic, guarantor, belonging to the institution)
Edition
Environmental Sciences Europe, HEIDELBERG, GERMANY, Springer-Verlag, GmbH, Environmental Sciences Europe, 2019, 2190-4715
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10511 Environmental sciences
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 5.394
RIV identification code
RIV/00216224:14310/19:00110362
Organization unit
Faculty of Science
UT WoS
000459786300001
Keywords in English
Flame retardants; ToxCast; AOP; Prioritization; Hazard; Mechanisms of toxicity
Tags
Tags
International impact, Reviewed
Změněno: 27/5/2020 09:09, RNDr. Kateřina Nováková, Ph.D.
Abstract
V originále
BackgroundFlame retardants (FRs) are used in most consumer products and textiles to comply with current flammability standards. After the restriction of polybrominated diphenyl ethers, a large number of chemically diverse replacement FRs are increasingly used, but the risk they represent is not yet properly evaluated and their toxicity pathways are still poorly understood.ApproachWe collected in vivo toxicological information on 62 (including 52 non-regulated) FRs and established five prioritization categories (Cat I to V) based on data availability and toxicological concern. We then considered available in vitro toxicological data from ToxCast, as a complement to in vivo information. By combining these information sources, we then explored relevant toxicity mechanisms for nine selected FRs (Cat I) using the AOP (Adverse Outcome Pathway) framework.ResultsFor 20 FRs (Cat V), toxicological data on mammals were absent. Data available were scarce for another 22 FRs, of which 14 FRs (Cat II) may be of toxicological concern. We found substantial information for only ten replacement FRs, of which nine (Cat I) present some toxicological concern: tris-2-chloroethyl phosphate (TCEP), tris(1,3-dichloropropyl)phosphate (TDCIPP), triphenyl phosphate (TPhP), tricresyl phosphate (TMPP), tetrabromobisphenol A (TBBPA), tri-n-butyl phosphate (TNBP), tri(2-butoxyethyl) phosphate (TBOEP), tris(1-chloro-2-propyl) phosphate (TCIPP), 2-ethylhexyl diphenyl phosphate (EHDPP). ToxCast results confirmed in vivo based categorization for several FRs and identified potential molecular targets. For the nine Cat I FRs, we identified several molecular targets, health outcomes and some potential AOPs. However, the complete toxicity pathways leading from molecular targets to adverse health outcomes are still unknown, with the exception of TBBPA-induced neurotoxicity.ConclusionsThe approach presented in this study was particularly useful for the categorization of a large group of replacement FRs with relatively low data availability. We highlight priority compounds that critically need more toxicological studies or FRs for which regulatory measures could be envisaged. Our research also suggests that high toxicity indicated by ToxCast is particularly relevant for predicting higher hazard in vivo. Finally, we indicate several gaps and directions for future research, such as molecular targets that could be tested in vitro and health outcomes for cohort studies.
Links
| EF16_013/0001761, research and development project |
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| LM2015051, research and development project |
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| 733032, interní kód MU |
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