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@article{1548992, author = {Cao, Fangjie and Souders, Christopher L. and Li, Pengfei and Adamovský, Ondřej and Pang, Sen and Qiu, Lihong and Martyniuk, Christopher J.}, article_location = {OXFORD}, article_number = {January}, doi = {http://dx.doi.org/10.1016/j.chemosphere.2018.09.105}, keywords = {Ziram; Zebrafish embryos; Mitochondrial bioenergetics; Dark/light preference; Gene expression; Dopamine system}, language = {eng}, issn = {0045-6535}, journal = {Chemosphere}, title = {Developmental toxicity of the fungicide ziram in zebrafish (Danio rerio)}, url = {https://www.sciencedirect.com/science/article/pii/S0045653518317600?via%3Dihub}, volume = {214}, year = {2019} }
TY - JOUR ID - 1548992 AU - Cao, Fangjie - Souders, Christopher L. - Li, Pengfei - Adamovský, Ondřej - Pang, Sen - Qiu, Lihong - Martyniuk, Christopher J. PY - 2019 TI - Developmental toxicity of the fungicide ziram in zebrafish (Danio rerio) JF - Chemosphere VL - 214 IS - January SP - 303-313 EP - 303-313 PB - PERGAMON-ELSEVIER SCIENCE LTD SN - 00456535 KW - Ziram KW - Zebrafish embryos KW - Mitochondrial bioenergetics KW - Dark/light preference KW - Gene expression KW - Dopamine system UR - https://www.sciencedirect.com/science/article/pii/S0045653518317600?via%3Dihub L2 - https://www.sciencedirect.com/science/article/pii/S0045653518317600?via%3Dihub N2 - Ziram is a broad spectrum pesticide that belongs to the class of dimethyl-dithiocarbamate (DTC) fungicides. The objectives of this study were to assess the effects of ziram in developing zebrafish. Ziram was highly toxic to zebrafish embryos, with a 96-h LC50 value of 1082.54 nM (similar to 0.33 mg/L). Zebrafish embryos at 6 h post-fertilization (hpf) were exposed to solvent control (0.1% DMSO), or one dose of 1, 10, 100, and 1000 nM ziram for 96 h. Ziram induced lethality in a dose-dependent manner, decreased hatching rate and heartbeat, and caused wavy deformities at 72 and 96 hpf at 100 and 1000 nM. Basal oxygen consumption rates of zebrafish at 24 hpf were decreased with 1000 nM, suggesting that ziram affects oxidative phosphorylation. We also measured the expression of transcripts associated with the oxidative stress response (sod] and sod2) and dopamine receptor signaling at similar to 96 h of exposure. There was no difference in the expression of genes related to oxidative stress, nor those related to the dopamine system. Locomotor activity was also assessed in larval zebrafish (7 dpf), and ziram increased total activity, the velocity in light zone, and total distance moved at 10 nM, while it decreased the mean time spent in the dark zone at 1 and 10 nM. Behavioral responses were dependent upon the time point and clutch examined. These data demonstrate that ziram negatively impacts embryonic development (i.e. mortality, hatching, heartbeat and notochord development) of zebrafish, decreases basal respiration of embryos, and alters behavioral responses in larvae. ER -
CAO, Fangjie, Christopher L. SOUDERS, Pengfei LI, Ondřej ADAMOVSKÝ, Sen PANG, Lihong QIU and Christopher J. MARTYNIUK. Developmental toxicity of the fungicide ziram in zebrafish (Danio rerio). \textit{Chemosphere}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2019, vol.~214, January, p.~303-313. ISSN~0045-6535. Available from: https://dx.doi.org/10.1016/j.chemosphere.2018.09.105.
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