Widespread occurrence of retinoids in water bodies associated
with cyanobacterial blooms dominated by diverse species

J 2019

Widespread occurrence of retinoids in water bodies associated with cyanobacterial blooms dominated by diverse species

SEHNAL, Luděk, Tereza PROCHÁZKOVÁ, Marie SMUTNÁ, Jiří KOHOUTEK, Olga LEPSOVA-SKACELOVA et. al.

Basic information

Original name

Widespread occurrence of retinoids in water bodies associated with cyanobacterial blooms dominated by diverse species

Authors

SEHNAL, Luděk (203 Czech Republic, belonging to the institution), Tereza PROCHÁZKOVÁ (203 Czech Republic, belonging to the institution), Marie SMUTNÁ (203 Czech Republic, belonging to the institution), Jiří KOHOUTEK (203 Czech Republic, belonging to the institution), Olga LEPSOVA-SKACELOVA (203 Czech Republic) and Klára HILSCHEROVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Water Research, OXFORD, PERGAMON-ELSEVIER SCIENCE LTD, 2019, 0043-1354

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10503 Water resources

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Full Text

Impact factor

Impact factor: 9.130

RIV identification code

RIV/00216224:14310/19:00107569

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.watres.2019.03.009

UT WoS

000466618400013

Keywords in English

Cyanobacteria; Retinoids; Water bloom; Retinoid-like activity

Abstract

V originále

Cyanobacterial blooms represent a worldwide problem in freshwater as well as marine ecosystems as producers of various toxic compounds. This study provides environmentally important information about the common presence of mixtures of retinoids in various water bodies associated with the occurrence of cyanobacterial blooms dominated by many different species. The study documents, for the first time, that retinoids are produced by environmental cyanobacterial blooms dominated by species belonging to different genera such as Microcystis, Dolichospermum, Planktothrix, Woronichinia, Pseudanabaena and others. Samples of biomass of cyanobacterial blooms and their surrounding water were collected from seventeen independent freshwater bodies across the Czech Republic during summer 2015. Retinoid-like activity was detected by an in vitro reporter gene bioassay in water samples from 8 out of 17 localities with a maximal activity of 263 ng all-trans retinoic acid equivalent (REQ)/L. In comparison, in vitro assessment of biomass extracts documented retinoid-like activity at 11 out of 17 localities with a maximal retinoid-like activity of 867 ng REQ/g dry mass (dm). Individual retinoids were detected by chemical analyses in all water samples and in 16 out of 17 biomass samples with 4keto-retinal and all trans 5,6epoxy retinoic acid being detected in aquatic ecosystems for the first time. Further, all-trans 4keto retinoic acid and retinal were the most commonly detected compounds in both types of samples. With respect to retinoid-like activity, a large proportion was explained in some samples by contributions of individual detected retinoids calculated from their concentrations and relative potencies. However, results also indicate that other unknown compounds with a retinoic acid receptor-mediated mode of action were present. The revealed widespread production of retinoids by cyanobacterial blooms dominated by diverse species across various aquatic ecosystems and their common presence in both biomass and surrounding water raises concern namely because some retinoids belong to the most potent teratogens. These compounds need to be taken into consideration in the assessment of risks associated with massive cyanobacterial blooms.

Links

EF16_013/0001761, research and development project

Name: RECETOX RI

GA18-15199S, research and development project

Name: Bioaktivní látky ze sinic ovlivňující signálování jaderných receptorů a vývoj obratlovců

Investor: Czech Science Foundation

LM2015051, research and development project

Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

SEHNAL, Luděk, Tereza PROCHÁZKOVÁ, Marie SMUTNÁ, Jiří KOHOUTEK, Olga LEPSOVA-SKACELOVA and Klára HILSCHEROVÁ. Widespread occurrence of retinoids in water bodies associated with cyanobacterial blooms dominated by diverse species. Water Research. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2019, vol. 156, June, p. 136-147. ISSN 0043-1354. Available from: https://dx.doi.org/10.1016/j.watres.2019.03.009.

@article{1549381,
   author = {Sehnal, Luděk and Procházková, Tereza and Smutná, Marie and Kohoutek, Jiří and LepsovaandSkacelova, Olga and Hilscherová, Klára},
   article_location = {OXFORD},
   article_number = {June},
   doi = {http://dx.doi.org/10.1016/j.watres.2019.03.009},
   keywords = {Cyanobacteria; Retinoids; Water bloom; Retinoid-like activity},
   language = {eng},
   issn = {0043-1354},
   journal = {Water Research},
   title = {Widespread occurrence of retinoids in water bodies associated with cyanobacterial blooms dominated by diverse species},
   url = {https://www.sciencedirect.com/science/article/pii/S0043135419302210?via%3Dihub},
   volume = {156},
   year = {2019}
}

TY  - JOUR
ID  - 1549381
AU  - Sehnal, Luděk - Procházková, Tereza - Smutná, Marie - Kohoutek, Jiří - Lepsova-Skacelova, Olga - Hilscherová, Klára
PY  - 2019
TI  - Widespread occurrence of retinoids in water bodies associated with cyanobacterial blooms dominated by diverse species
JF  - Water Research
VL  - 156
IS  - June
SP  - 136-147
EP  - 136-147
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 00431354
KW  - Cyanobacteria
KW  - Retinoids
KW  - Water bloom
KW  - Retinoid-like activity
UR  - https://www.sciencedirect.com/science/article/pii/S0043135419302210?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S0043135419302210?via%3Dihub
N2  - Cyanobacterial blooms represent a worldwide problem in freshwater as well as marine ecosystems as producers of various toxic compounds. This study provides environmentally important information about the common presence of mixtures of retinoids in various water bodies associated with the occurrence of cyanobacterial blooms dominated by many different species. The study documents, for the first time, that retinoids are produced by environmental cyanobacterial blooms dominated by species belonging to different genera such as Microcystis, Dolichospermum, Planktothrix, Woronichinia, Pseudanabaena and others. Samples of biomass of cyanobacterial blooms and their surrounding water were collected from seventeen independent freshwater bodies across the Czech Republic during summer 2015. Retinoid-like activity was detected by an in vitro reporter gene bioassay in water samples from 8 out of 17 localities with a maximal activity of 263 ng all-trans retinoic acid equivalent (REQ)/L. In comparison, in vitro assessment of biomass extracts documented retinoid-like activity at 11 out of 17 localities with a maximal retinoid-like activity of 867 ng REQ/g dry mass (dm). Individual retinoids were detected by chemical analyses in all water samples and in 16 out of 17 biomass samples with 4keto-retinal and all trans 5,6epoxy retinoic acid being detected in aquatic ecosystems for the first time. Further, all-trans 4keto retinoic acid and retinal were the most commonly detected compounds in both types of samples. With respect to retinoid-like activity, a large proportion was explained in some samples by contributions of individual detected retinoids calculated from their concentrations and relative potencies. However, results also indicate that other unknown compounds with a retinoic acid receptor-mediated mode of action were present. The revealed widespread production of retinoids by cyanobacterial blooms dominated by diverse species across various aquatic ecosystems and their common presence in both biomass and surrounding water raises concern namely because some retinoids belong to the most potent teratogens. These compounds need to be taken into consideration in the assessment of risks associated with massive cyanobacterial blooms.
ER  -

SEHNAL, Luděk, Tereza PROCHÁZKOVÁ, Marie SMUTNÁ, Jiří KOHOUTEK, Olga LEPSOVA-SKACELOVA and Klára HILSCHEROVÁ. Widespread occurrence of retinoids in water bodies associated with cyanobacterial blooms dominated by diverse species. \textit{Water Research}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2019, vol.~156, June, p.~136-147. ISSN~0043-1354. Available from: https://dx.doi.org/10.1016/j.watres.2019.03.009.

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