J 2019

Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group

SCHUTZ, Katharina, Diana ALECSANDRU, Bodo GRIMBACHER, Jamanda HADDOCK, Annemarie BRUINING et. al.

Basic information

Original name

Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group

Authors

SCHUTZ, Katharina (276 Germany), Diana ALECSANDRU (826 United Kingdom of Great Britain and Northern Ireland), Bodo GRIMBACHER (276 Germany), Jamanda HADDOCK (826 United Kingdom of Great Britain and Northern Ireland), Annemarie BRUINING (528 Netherlands), Gertjan DRIESSEN (528 Netherlands), Esther DE VRIES (528 Netherlands), Peter M. VAN HAGEN, Ieneke HARTMANN (528 Netherlands), Francesco FRAIOLI (380 Italy), Cinzia MILITO (380 Italy), Milica MITREVSKI (380 Italy), Isabella QUINTI (380 Italy), Goffredo SERRA (380 Italy), Peter KELLEHER (826 United Kingdom of Great Britain and Northern Ireland), Michael LOEBINGER (826 United Kingdom of Great Britain and Northern Ireland), Jiří LITZMAN (203 Czech Republic, belonging to the institution), Věra POSTRÁNECKÁ (203 Czech Republic), Vojtěch THON (203 Czech Republic, guarantor, belonging to the institution), Judith BABAR (826 United Kingdom of Great Britain and Northern Ireland), Alison M. CONDLIFFE (826 United Kingdom of Great Britain and Northern Ireland), Andrew EXLEY (826 United Kingdom of Great Britain and Northern Ireland), Dinakantha KUMARARATNE (826 United Kingdom of Great Britain and Northern Ireland), Nick SCREATON (826 United Kingdom of Great Britain and Northern Ireland), Alison JONES (826 United Kingdom of Great Britain and Northern Ireland), Maria P. BONDIONI (380 Italy), Vassilios LOUGARIS (380 Italy), Alessandro PLEBANI (380 Italy), Annarosa SORESINA (380 Italy), Cesare SIRIGNANO (380 Italy), Giuseppe SPADARO (380 Italy), Nermeen GALAL (818 Egypt), Luis I. GONZALEZ-GRANADO (724 Spain), Sabine DETTMER (276 Germany), Robert STIRLING (36 Australia), Helen CHAPEL (826 United Kingdom of Great Britain and Northern Ireland), Mary LUCAS (826 United Kingdom of Great Britain and Northern Ireland), Smita PATEL (826 United Kingdom of Great Britain and Northern Ireland), Claire-Michele FARBER (56 Belgium), Isabelle MEYTS (56 Belgium), Arpan K. BANERJEE (826 United Kingdom of Great Britain and Northern Ireland), Scott HACKETT (826 United Kingdom of Great Britain and Northern Ireland), John R. HURST (826 United Kingdom of Great Britain and Northern Ireland), Klaus WARNATZ (276 Germany), Benjamin GATHMANN (276 Germany) and Ulrich BAUMANN (276 Germany)

Edition

Journal of Clinical Immunology, New York, Springer, 2019, 0271-9142

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30102 Immunology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 6.780

RIV identification code

RIV/00216224:14110/19:00110433

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s10875-018-0577-9

UT WoS

000458867500011

Keywords in English

Chest CT; CVID; primary antibody deficiency; bronchiectasis; bronchial pathology

Tags

14110114, podil, rivok

Tags

International impact, Reviewed
Změněno: 21/1/2020 07:03, Mgr. Tereza Miškechová

Abstract

V originále

Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial pathology in this patient group. One of the underlying reasons is the lack of a consensus methodology, a prerequisite to jointly document chest CT findings. We aimed to establish an international platform for the evaluation of bronchial pathology as assessed by chest CT and to describe the range of bronchial pathologies in patients with antibody deficiency. Ffteen immunodeficiency centres from 9 countries evaluated chest CT scans of patients with ADS using a predefined list of potential findings including an extent score for bronchiectasis. Data of 282 patients with ADS were collected. Patients with common variable immunodeficiency disorders (CVID) comprised the largest subgroup (232 patients, 82.3%). Eighty percent of CVID patients had radiological evidence of bronchial pathology including bronchiectasis in 61%, bronchial wall thickening in 44% and mucus plugging in 29%. Bronchiectasis was detected in 44% of CVID patients aged less than 20years. Cough was a better predictor for bronchiectasis than spirometry values. Delay of diagnosis as well as duration of disease correlated positively with presence of bronchiectasis. The use of consensus diagnostic criteria and a pre-defined list of bronchial pathologies allows for comparison of chest CT data in multicentre studies. Our data suggest a high prevalence of bronchial pathology in CVID due to late diagnosis or duration of disease.

Links

EF15_003/0000469, research and development project
Name: Cetocoen Plus
Displayed: 2/11/2024 03:50