Další formáty:
BibTeX
LaTeX
RIS
@article{1549657, author = {Mach, Samuel and Jegorov, Alexandr and Šimek, Zdeněk}, article_location = {Heidelberg}, article_number = {20}, doi = {http://dx.doi.org/10.1007/s11356-019-05398-2}, keywords = {Obeticholic acid; Metabolites; Fish; Ameiurus nebulosus; UPLC; HRMS}, language = {eng}, issn = {0944-1344}, journal = {Environmental Science and Pollution Research}, title = {Metabolism of obeticholic acid in brown bullhead (Ameiurus nebulosus)}, url = {https://link.springer.com/article/10.1007%2Fs11356-019-05398-2}, volume = {26}, year = {2019} }
TY - JOUR ID - 1549657 AU - Mach, Samuel - Jegorov, Alexandr - Šimek, Zdeněk PY - 2019 TI - Metabolism of obeticholic acid in brown bullhead (Ameiurus nebulosus) JF - Environmental Science and Pollution Research VL - 26 IS - 20 SP - 20316-20324 EP - 20316-20324 PB - Springer Heidelberg SN - 09441344 KW - Obeticholic acid KW - Metabolites KW - Fish KW - Ameiurus nebulosus KW - UPLC KW - HRMS UR - https://link.springer.com/article/10.1007%2Fs11356-019-05398-2 L2 - https://link.springer.com/article/10.1007%2Fs11356-019-05398-2 N2 - Analysis of brown bullhead (Ameiurus nebulosus) bile by ultra performance liquid chromatography high-resolution mass spectrometry (UPLC/HRMS) revealed a series of bile acids similar to those found in humans. Accordingly, we chose this fish as a model organism to examine the metabolism of obeticholic acid, a bile acid used to treat a number of human liver diseases and the one that has the potential to occur as an environmental contaminant. The taurine and glycine conjugates of obeticholic acid and keto-obeticholic acid were identified, as well as the d-cysteinolic acid conjugate of obeticholic acid, likely a metabolite specific to fish. In addition, metabolites of obeticholic acid (sulphate and glucuronide) and several hydroxy-obeticholic acid derivatives were found, representing typical pathways of primary and secondary steroid metabolism. Brown bullhead exposed to obeticholic acid at a dose of 100 mg/kg gave no overt signs of distress or toxicity. ER -
MACH, Samuel, Alexandr JEGOROV a Zdeněk ŠIMEK. Metabolism of obeticholic acid in brown bullhead (Ameiurus nebulosus). \textit{Environmental Science and Pollution Research}. Heidelberg: Springer Heidelberg, 2019, roč.~26, č.~20, s.~20316-20324. ISSN~0944-1344. Dostupné z: https://dx.doi.org/10.1007/s11356-019-05398-2.
|