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@article{1549657,
author = {Mach, Samuel and Jegorov, Alexandr and Šimek, Zdeněk},
article_location = {Heidelberg},
article_number = {20},
doi = {http://dx.doi.org/10.1007/s11356-019-05398-2},
keywords = {Obeticholic acid; Metabolites; Fish; Ameiurus nebulosus; UPLC; HRMS},
language = {eng},
issn = {0944-1344},
journal = {Environmental Science and Pollution Research},
title = {Metabolism of obeticholic acid in brown bullhead (Ameiurus nebulosus)},
url = {https://link.springer.com/article/10.1007%2Fs11356-019-05398-2},
volume = {26},
year = {2019}
}
TY - JOUR
ID - 1549657
AU - Mach, Samuel - Jegorov, Alexandr - Šimek, Zdeněk
PY - 2019
TI - Metabolism of obeticholic acid in brown bullhead (Ameiurus nebulosus)
JF - Environmental Science and Pollution Research
VL - 26
IS - 20
SP - 20316-20324
EP - 20316-20324
PB - Springer Heidelberg
SN - 09441344
KW - Obeticholic acid
KW - Metabolites
KW - Fish
KW - Ameiurus nebulosus
KW - UPLC
KW - HRMS
UR - https://link.springer.com/article/10.1007%2Fs11356-019-05398-2
L2 - https://link.springer.com/article/10.1007%2Fs11356-019-05398-2
N2 - Analysis of brown bullhead (Ameiurus nebulosus) bile by ultra performance liquid chromatography high-resolution mass spectrometry (UPLC/HRMS) revealed a series of bile acids similar to those found in humans. Accordingly, we chose this fish as a model organism to examine the metabolism of obeticholic acid, a bile acid used to treat a number of human liver diseases and the one that has the potential to occur as an environmental contaminant. The taurine and glycine conjugates of obeticholic acid and keto-obeticholic acid were identified, as well as the d-cysteinolic acid conjugate of obeticholic acid, likely a metabolite specific to fish. In addition, metabolites of obeticholic acid (sulphate and glucuronide) and several hydroxy-obeticholic acid derivatives were found, representing typical pathways of primary and secondary steroid metabolism. Brown bullhead exposed to obeticholic acid at a dose of 100 mg/kg gave no overt signs of distress or toxicity.
ER -
MACH, Samuel, Alexandr JEGOROV and Zdeněk ŠIMEK. Metabolism of obeticholic acid in brown bullhead (Ameiurus nebulosus). \textit{Environmental Science and Pollution Research}. Heidelberg: Springer Heidelberg, 2019, vol.~26, No~20, p.~20316-20324. ISSN~0944-1344. Available from: https://dx.doi.org/10.1007/s11356-019-05398-2.
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