Vliv mikrobiomu na vznik a vývoj kolorektálního karcinomu

ZWINSOVÁ, Barbora, Veronika BRYCHTOVÁ, Martina HRIVŇÁKOVÁ, Lenka ZDRAŽILOVÁ DUBSKÁ, Beatric BENCSIKOVÁ, Roman ŠEFR, Rudolf NENUTIL, Petra VÍDEŇSKÁ and Eva BUDINSKÁ. Vliv mikrobiomu na vznik a vývoj kolorektálního karcinomu (Role of the Microbiome in the Formation and Development of Colorectal Cancer). Klinická onkologie. Ambit Media, a.s., 2019, vol. 32, No 4, p. 261-269. ISSN 0862-495X. Available from: https://dx.doi.org/10.14735/amko2019261.

Basic information

• Original name: Vliv mikrobiomu na vznik a vývoj kolorektálního karcinomu
• Name in Czech: Vliv mikrobiomu na vznik a vývoj kolorektálního karcinomu
• Name (in English): Role of the Microbiome in the Formation and Development of Colorectal Cancer
• Authors: ZWINSOVÁ, Barbora, Veronika BRYCHTOVÁ, Martina HRIVŇÁKOVÁ, Lenka ZDRAŽILOVÁ DUBSKÁ, Beatric BENCSIKOVÁ, Roman ŠEFR, Rudolf NENUTIL, Petra VÍDEŇSKÁ and Eva BUDINSKÁ.
• Edition: Klinická onkologie, Ambit Media, a.s. 2019, 0862-495X.

Other information

• Original language: Czech
• Type of outcome: Article in a journal
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Doi: http://dx.doi.org/10.14735/amko2019261
• Keywords (in Czech): kolorektální karcinom, heterogenita, střevní mikrobiom, dysbióza
• Keywords in English: colorectal cancer, heterogeneity, gut microbiome, dysbiosis
• Tags: Reviewed

Abstract (in English)

Background: The clinical, histopathological, and molecular characteristics of colorectal cancer vary considerably. Factors associated with the heterogeneity of this disease and with understanding the effects of heterogeneity on disease progression and response to therapy are critical for the better stratification of patients and the development of new therapeutic methods. Although studies have focused mainly on tumor molecular profiling, current molecular predictive and prognostic factors are relevant to specific groups of colorectal cancer patients and are mostly used to predict the applicability of targeted biological agents rather than to predict their benefits. Molecular profiling fails to capture aspects important for tumor growth and aggressiveness, including the tumor microenvironment. The gut microbiome, consisting of specific communities of all commensal, symbiotic, and pathogenic microorganisms, has been shown to have a significant impact on the development of many diseases, including Crohn’s disease, type II diabetes, and obesity. Recent studies have indicated that long-term dysbiosis of the intestinal microflora can influence the development and progression of colorectal cancer, as well as tumor aggressiveness and response to treatment. Conclusion: This review article summarizes current knowledge of the gut microbiome in colorectal cancer, including the various mechanisms by which the gut microbiome affects the intestinal wall, thereby contributing to the development and progression of colorectal cancer.