k 2019

The cytotoxic effect of ferrocene derivatives in combination with radiotherapy against cervical carcinoma cells

SKOUPILOVÁ, Hana, Vladimír RAK, Jindřich KARBAN, Jiří PINKAS, Roman HRSTKA et. al.

Basic information

Original name

The cytotoxic effect of ferrocene derivatives in combination with radiotherapy against cervical carcinoma cells

Name in Czech

Cytotoxický účinek derivátů ferocenu v kombinaci s radioterapií v buněčných liniích karcinomu děložního čípku

Authors

SKOUPILOVÁ, Hana, Vladimír RAK, Jindřich KARBAN, Jiří PINKAS and Roman HRSTKA

Edition

Chemistry and biology of phytohormones and related substances, 2019

Other information

Type of outcome

Prezentace na konferencích

Confidentiality degree

není předmětem státního či obchodního tajemství
Změněno: 22/8/2019 12:56, Mgr. Hana Kubušová, Ph.D.

Abstract

V originále

Cervical cancer is the the second most frequent female malignancy. Despite the availability of preventive screening program and vaccination against most prevalent „high-risk“ human papillomaviruses (HPV), approximately 400 women die due to cervical cancer each year in the Czech Republic. Optimal treatment choice depends on the stage of the disease. Early stages are treated by surgery. More advanced stages are usually treated with a combination of radiotherapy and chemotherapy. Most commonly used chemotherapeutic drug is still cisplatin, which has a good antitumor effect but also serious toxicity. This fact led us to the synthesis and testing of new potential anti-cancer organometallic compounds. A series of new structures based on ferrocene moiety was tested in vitro and showed even better efficiency than cisplatin.