| SEDLÁKOVÁ, Veronika, Michaela KLOUČKOVÁ, Zuzana GARLÍKOVÁ, Kateřina VAŠÍČKOVÁ, Josef JAROŠ, Mário KANDRA, Hana KOTASOVÁ a Aleš HAMPL. Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips. Drug Discovery Today. Oxford (England): Elsevier Sci Ltd., roč. 24, č. 4, s. 971-982. ISSN 1359-6446. doi:10.1016/j.drudis.2019.03.006. 2019. |
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@article{1550215,
author = {Sedláková, Veronika and Kloučková, Michaela and Garlíková, Zuzana and Vašíčková, Kateřina and Jaroš, Josef and Kandra, Mário and Kotasová, Hana and Hampl, Aleš},
article_location = {Oxford (England)},
article_number = {4},
doi = {http://dx.doi.org/10.1016/j.drudis.2019.03.006},
keywords = {On-a-Chip; Alveolar-Capillary Barrier; In-vitro Model; Airway Wall; Extracellular-Matrix; Endothelial-Cells; Epithelial-Cells; High-Throughput; Stem-Cells; Lung},
language = {eng},
issn = {1359-6446},
journal = {Drug Discovery Today},
title = {Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips},
url = {https://www.sciencedirect.com/science/article/pii/S1359644618304458?via%3Dihub},
volume = {24},
year = {2019}
}
TY - JOUR
ID - 1550215
AU - Sedláková, Veronika - Kloučková, Michaela - Garlíková, Zuzana - Vašíčková, Kateřina - Jaroš, Josef - Kandra, Mário - Kotasová, Hana - Hampl, Aleš
PY - 2019
TI - Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips
JF - Drug Discovery Today
VL - 24
IS - 4
SP - 971-982
EP - 971-982
PB - Elsevier Sci Ltd.
SN - 13596446
KW - On-a-Chip
KW - Alveolar-Capillary Barrier
KW - In-vitro Model
KW - Airway Wall
KW - Extracellular-Matrix
KW - Endothelial-Cells
KW - Epithelial-Cells
KW - High-Throughput
KW - Stem-Cells
KW - Lung
UR - https://www.sciencedirect.com/science/article/pii/S1359644618304458?via%3Dihub
L2 - https://www.sciencedirect.com/science/article/pii/S1359644618304458?via%3Dihub
N2 - The human respiratory system is continuously exposed to varying levels of hazardous substances ranging from environmental toxins to purposely administered drugs. If the noxious effects exceed the inherent regenerative capacity of the respiratory system, injured tissue undergoes complex remodeling that can significantly affect lung function and lead to various diseases. Advanced near-to-native in vitro lung models are required to understand the mechanisms involved in pulmonary damage and repair and to reliably test the toxicity of compounds to lung tissue. This review is an overview of the development of in vitro respiratory system models used for study of lung diseases. It includes discussion of using these models for environmental toxin assessment and pulmonary toxicity screening.
ER -
SEDLÁKOVÁ, Veronika, Michaela KLOUČKOVÁ, Zuzana GARLÍKOVÁ, Kateřina VAŠÍČKOVÁ, Josef JAROŠ, Mário KANDRA, Hana KOTASOVÁ a Aleš HAMPL. Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips. \textit{Drug Discovery Today}. Oxford (England): Elsevier Sci Ltd., roč.~24, č.~4, s.~971-982. ISSN~1359-6446. doi:10.1016/j.drudis.2019.03.006. 2019.
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