SEDLÁKOVÁ, Veronika, Michaela KLOUČKOVÁ, Zuzana GARLÍKOVÁ, Kateřina VAŠÍČKOVÁ, Josef JAROŠ, Mário KANDRA, Hana KOTASOVÁ and Aleš HAMPL. Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips. Drug Discovery Today. Oxford (England): Elsevier Sci Ltd., 2019, vol. 24, No 4, p. 971-982. ISSN 1359-6446. Available from: https://dx.doi.org/10.1016/j.drudis.2019.03.006. |
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@article{1550215, author = {Sedláková, Veronika and Kloučková, Michaela and Garlíková, Zuzana and Vašíčková, Kateřina and Jaroš, Josef and Kandra, Mário and Kotasová, Hana and Hampl, Aleš}, article_location = {Oxford (England)}, article_number = {4}, doi = {http://dx.doi.org/10.1016/j.drudis.2019.03.006}, keywords = {On-a-Chip; Alveolar-Capillary Barrier; In-vitro Model; Airway Wall; Extracellular-Matrix; Endothelial-Cells; Epithelial-Cells; High-Throughput; Stem-Cells; Lung}, language = {eng}, issn = {1359-6446}, journal = {Drug Discovery Today}, title = {Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips}, url = {https://www.sciencedirect.com/science/article/pii/S1359644618304458?via%3Dihub}, volume = {24}, year = {2019} }
TY - JOUR ID - 1550215 AU - Sedláková, Veronika - Kloučková, Michaela - Garlíková, Zuzana - Vašíčková, Kateřina - Jaroš, Josef - Kandra, Mário - Kotasová, Hana - Hampl, Aleš PY - 2019 TI - Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips JF - Drug Discovery Today VL - 24 IS - 4 SP - 971-982 EP - 971-982 PB - Elsevier Sci Ltd. SN - 13596446 KW - On-a-Chip KW - Alveolar-Capillary Barrier KW - In-vitro Model KW - Airway Wall KW - Extracellular-Matrix KW - Endothelial-Cells KW - Epithelial-Cells KW - High-Throughput KW - Stem-Cells KW - Lung UR - https://www.sciencedirect.com/science/article/pii/S1359644618304458?via%3Dihub L2 - https://www.sciencedirect.com/science/article/pii/S1359644618304458?via%3Dihub N2 - The human respiratory system is continuously exposed to varying levels of hazardous substances ranging from environmental toxins to purposely administered drugs. If the noxious effects exceed the inherent regenerative capacity of the respiratory system, injured tissue undergoes complex remodeling that can significantly affect lung function and lead to various diseases. Advanced near-to-native in vitro lung models are required to understand the mechanisms involved in pulmonary damage and repair and to reliably test the toxicity of compounds to lung tissue. This review is an overview of the development of in vitro respiratory system models used for study of lung diseases. It includes discussion of using these models for environmental toxin assessment and pulmonary toxicity screening. ER -
SEDLÁKOVÁ, Veronika, Michaela KLOUČKOVÁ, Zuzana GARLÍKOVÁ, Kateřina VAŠÍČKOVÁ, Josef JAROŠ, Mário KANDRA, Hana KOTASOVÁ and Aleš HAMPL. Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips. \textit{Drug Discovery Today}. Oxford (England): Elsevier Sci Ltd., 2019, vol.~24, No~4, p.~971-982. ISSN~1359-6446. Available from: https://dx.doi.org/10.1016/j.drudis.2019.03.006.
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