Options for modeling the respiratory system: inserts, scaffolds
and microfluidic chips

J 2019

Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips

SEDLÁKOVÁ, Veronika, Michaela KLOUČKOVÁ, Zuzana GARLÍKOVÁ, Kateřina VAŠÍČKOVÁ, Josef JAROŠ et. al.

Basic information

Original name

Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips

Authors

SEDLÁKOVÁ, Veronika (203 Czech Republic, guarantor, belonging to the institution), Michaela KLOUČKOVÁ (203 Czech Republic, belonging to the institution), Zuzana GARLÍKOVÁ (203 Czech Republic, belonging to the institution), Kateřina VAŠÍČKOVÁ (203 Czech Republic, belonging to the institution), Josef JAROŠ (203 Czech Republic, belonging to the institution), Mário KANDRA (703 Slovakia, belonging to the institution), Hana KOTASOVÁ (203 Czech Republic, belonging to the institution) and Aleš HAMPL (203 Czech Republic, belonging to the institution)

Edition

Drug Discovery Today, Oxford (England), Elsevier Sci Ltd. 2019, 1359-6446

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 7.321

RIV identification code

RIV/00216224:14110/19:00108503

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.drudis.2019.03.006

UT WoS

000467511200007

Keywords in English

On-a-Chip; Alveolar-Capillary Barrier; In-vitro Model; Airway Wall; Extracellular-Matrix; Endothelial-Cells; Epithelial-Cells; High-Throughput; Stem-Cells; Lung

Abstract

V originále

The human respiratory system is continuously exposed to varying levels of hazardous substances ranging from environmental toxins to purposely administered drugs. If the noxious effects exceed the inherent regenerative capacity of the respiratory system, injured tissue undergoes complex remodeling that can significantly affect lung function and lead to various diseases. Advanced near-to-native in vitro lung models are required to understand the mechanisms involved in pulmonary damage and repair and to reliably test the toxicity of compounds to lung tissue. This review is an overview of the development of in vitro respiratory system models used for study of lung diseases. It includes discussion of using these models for environmental toxin assessment and pulmonary toxicity screening.

Links

MUNI/A/1298/2017, interní kód MU

Name: Zdroje pro tkáňové inženýrství 8 (Acronym: TissueEng 8)

Investor: Masaryk University, Category A

MUNI/A/1565/2018, interní kód MU

Name: Zdroje pro tkáňové inženýrství 9 (Acronym: TissueEng 9)

Investor: Masaryk University, Category A

NV16-31501A, research and development project

Name: Tkáňové inženýrství epitelů: Buňky a protokoly pro regenerativní medicínu

Citovat

SEDLÁKOVÁ, Veronika, Michaela KLOUČKOVÁ, Zuzana GARLÍKOVÁ, Kateřina VAŠÍČKOVÁ, Josef JAROŠ, Mário KANDRA, Hana KOTASOVÁ and Aleš HAMPL. Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips. Drug Discovery Today. Oxford (England): Elsevier Sci Ltd., 2019, vol. 24, No 4, p. 971-982. ISSN 1359-6446. Available from: https://dx.doi.org/10.1016/j.drudis.2019.03.006.

@article{1550215,
   author = {Sedláková, Veronika and Kloučková, Michaela and Garlíková, Zuzana and Vašíčková, Kateřina and Jaroš, Josef and Kandra, Mário and Kotasová, Hana and Hampl, Aleš},
   article_location = {Oxford (England)},
   article_number = {4},
   doi = {http://dx.doi.org/10.1016/j.drudis.2019.03.006},
   keywords = {On-a-Chip; Alveolar-Capillary Barrier; In-vitro Model; Airway Wall; Extracellular-Matrix; Endothelial-Cells; Epithelial-Cells; High-Throughput; Stem-Cells; Lung},
   language = {eng},
   issn = {1359-6446},
   journal = {Drug Discovery Today},
   title = {Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips},
   url = {https://www.sciencedirect.com/science/article/pii/S1359644618304458?via%3Dihub},
   volume = {24},
   year = {2019}
}

TY  - JOUR
ID  - 1550215
AU  - Sedláková, Veronika - Kloučková, Michaela - Garlíková, Zuzana - Vašíčková, Kateřina - Jaroš, Josef - Kandra, Mário - Kotasová, Hana - Hampl, Aleš
PY  - 2019
TI  - Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips
JF  - Drug Discovery Today
VL  - 24
IS  - 4
SP  - 971-982
EP  - 971-982
PB  - Elsevier Sci Ltd.
SN  - 13596446
KW  - On-a-Chip
KW  - Alveolar-Capillary Barrier
KW  - In-vitro Model
KW  - Airway Wall
KW  - Extracellular-Matrix
KW  - Endothelial-Cells
KW  - Epithelial-Cells
KW  - High-Throughput
KW  - Stem-Cells
KW  - Lung
UR  - https://www.sciencedirect.com/science/article/pii/S1359644618304458?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S1359644618304458?via%3Dihub
N2  - The human respiratory system is continuously exposed to varying levels of hazardous substances ranging from environmental toxins to purposely administered drugs. If the noxious effects exceed the inherent regenerative capacity of the respiratory system, injured tissue undergoes complex remodeling that can significantly affect lung function and lead to various diseases. Advanced near-to-native in vitro lung models are required to understand the mechanisms involved in pulmonary damage and repair and to reliably test the toxicity of compounds to lung tissue. This review is an overview of the development of in vitro respiratory system models used for study of lung diseases. It includes discussion of using these models for environmental toxin assessment and pulmonary toxicity screening.
ER  -

SEDLÁKOVÁ, Veronika, Michaela KLOUČKOVÁ, Zuzana GARLÍKOVÁ, Kateřina VAŠÍČKOVÁ, Josef JAROŠ, Mário KANDRA, Hana KOTASOVÁ and Aleš HAMPL. Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips. \textit{Drug Discovery Today}. Oxford (England): Elsevier Sci Ltd., 2019, vol.~24, No~4, p.~971-982. ISSN~1359-6446. Available from: https://dx.doi.org/10.1016/j.drudis.2019.03.006.

Detailed Information on Publication Record