J 2019

Mixed copper(ii)-phenanthroline complexes induce cell death of ovarian cancer cells by evoking the unfolded protein response

MORÁŇ, Lukáš, Tiziana PIVETTA, Sebastiano MASURI, Kateřina VAŠÍČKOVÁ, Franziska WALTER et. al.

Basic information

Original name

Mixed copper(ii)-phenanthroline complexes induce cell death of ovarian cancer cells by evoking the unfolded protein response

Authors

MORÁŇ, Lukáš (203 Czech Republic, belonging to the institution), Tiziana PIVETTA (380 Italy), Sebastiano MASURI (380 Italy), Kateřina VAŠÍČKOVÁ (203 Czech Republic, belonging to the institution), Franziska WALTER (372 Ireland), Jochen PREHN (372 Ireland), Moustafa ELKALAF (203 Czech Republic), Jan TRNKA (203 Czech Republic), Josef HAVEL (203 Czech Republic, belonging to the institution) and Petr VAŇHARA (203 Czech Republic, guarantor, belonging to the institution)

Edition

Metallomics, Cambridge, ROYAL SOC CHEMISTRY, 2019, 1756-5901

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 3.796

RIV identification code

RIV/00216224:14110/19:00110493

Organization unit

Faculty of Medicine

DOI

UT WoS

000487053000003

Keywords in English

ENDOPLASMIC-RETICULUM STRESS; LIGAND COPPER(II) COMPLEXES; DNA CLEAVAGE; TUMOR-CELLS; CISPLATIN; 1_10-PHENANTHROLINE; PHENANTHROLINE; APOPTOSIS; BINDING; CYTOTOXICITY

Tags

Tags

International impact, Reviewed
Změněno: 1/4/2020 14:31, Mgr. Marie Šípková, DiS.

Abstract

V originále

There is an ongoing need for the development of new cancer therapeutics that combine high cytotoxic efficiency with low side effects, and also override resistance to the first-line chemotherapeutics. Copper(II)–phenanthroline complexes are promising compounds that were shown previously to induce an immediate cytotoxic response over a panel of tumor cell lines in vitro. The molecular mechanism, however, remained unresolved. In this work we performed a thorough study of the copper(II)–phenanthroline complexes containing different imidazolidine-2-thione ligands in ovarian cancer cells, and revealed that these complexes induce endoplasmic reticulum (ER) stress and subsequently cell death mediated by the unfolded protein response. Alleviation of the ER-stress by tauroursodeoxycholic acid (TUDCA) attenuated the cytotoxic effects. In summary, we have identified a novel, ER-dependent, molecular mechanism mediating cytotoxic effects of copper(II)–phenanthroline complexes.

Links

EE2.3.20.0185, research and development project
Name: Centrum analýz a modelování tkání a orgánů
LM2015062, research and development project
Name: Národní infrastruktura pro biologické a medicínské zobrazování
Investor: Ministry of Education, Youth and Sports of the CR
MUNI/A/1565/2018, interní kód MU
Name: Zdroje pro tkáňové inženýrství 9 (Acronym: TissueEng 9)
Investor: Masaryk University, Category A