Eye movement tracking represents royal pathway to understand human sensorimotor activity, especially with respect to specific environments. Human sensorimotor activity is an important factor by which we can infer cognitive processes, describe and predict human performance and also measure and compare individual differences among people. The most significant indicator of human sensorimotor activity is an analysis of one's areas of visual interest in his/her surroundings (Holmqvist, 2011). Regarding this, next to the real world settings, eye tracking finds huge potential in the context of virtual reality (VR). VR capabilities providing environmentally valid reality-approaching dynamic stimuli while maintaining high level of experimental control allow researchers to collect complex and accurate data about human behavioral and decision-making processes (Loomis et al., 1999). Virtual interfaces equipped with the functionality to track and record data about areas of human visual interest and virtual locomotion provide comprehensive evidence about users behaviors and may be applied in many research areas - e.g. navigation, perception, visual cognition (Stachoň et al., 2018) or cross-cultural research (Miellet et al., 2012). In the presented contribution we describe specific head-mounted-display-based experimental interface equipped with the ET technology, which we have designed for the research of information search activity and spatial navigation activity in immersive virtual environments. We discuss HW, SW and methodological implications, possibilities and limits of this ET implementation for VR and finally we propose its use for cross-cultural research of human perception and cognitive processes.