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@article{1553877,
author = {Fiedorová, Kristýna and Radvanský, Matěj and Bosák, Juraj and Grombiříková, Hana and Němcová, Eva and Králíčková, Pavlina and Černochová, Michaela and Kotásková, Iva and Lexa, Matej and Litzman, Jiří and Šmajs, David and Freiberger, Tomáš},
article_location = {LAUSANNE},
article_number = {1914},
doi = {http://dx.doi.org/10.3389/fimmu.2019.01914},
keywords = {CVID; IgA; gut microbiota; gut microbiome; gut mycobiota; gut mycobiome; fungal microbiota; fungal microbiome},
language = {eng},
issn = {1664-3224},
journal = {Frontiers in Immunology},
title = {Bacterial but Not Fungal Gut Microbiota Alterations Are Associated With Common Variable Immunodeficiency (CVID) Phenotype},
url = {https://www.frontiersin.org/articles/10.3389/fimmu.2019.01914/full},
volume = {10},
year = {2019}
}
TY - JOUR
ID - 1553877
AU - Fiedorová, Kristýna - Radvanský, Matěj - Bosák, Juraj - Grombiříková, Hana - Němcová, Eva - Králíčková, Pavlina - Černochová, Michaela - Kotásková, Iva - Lexa, Matej - Litzman, Jiří - Šmajs, David - Freiberger, Tomáš
PY - 2019
TI - Bacterial but Not Fungal Gut Microbiota Alterations Are Associated With Common Variable Immunodeficiency (CVID) Phenotype
JF - Frontiers in Immunology
VL - 10
IS - 1914
SP - 1-14
EP - 1-14
PB - FRONTIERS MEDIA SA
SN - 16643224
KW - CVID
KW - IgA
KW - gut microbiota
KW - gut microbiome
KW - gut mycobiota
KW - gut mycobiome
KW - fungal microbiota
KW - fungal microbiome
UR - https://www.frontiersin.org/articles/10.3389/fimmu.2019.01914/full
L2 - https://www.frontiersin.org/articles/10.3389/fimmu.2019.01914/full
N2 - Common Variable Immunodeficiency (CVID) is the most frequent symptomatic immune disorder characterized by reduced serum immunoglobulins. Patients often suffer from infectious and serious non-infectious complications which impact their life tremendously. The monogenic cause has been revealed in a minority of patients so far, indicating the role of multiple genes and environmental factors in CVID etiology. Using 16S and ITS rRNA amplicon sequencing, we analyzed the bacterial and fungal gut microbiota, respectively, in a group of 55 participants constituting of CVID patients and matched healthy controls including 16 case-control pairs living in the same household, to explore possible associations between gut microbiota composition and disease phenotype. We revealed less diverse and significantly altered bacterial but not fungal gut microbiota in CVID patients, which additionally appeared to be associated with a more severe disease phenotype. The factor of sharing the same household impacted both bacterial and fungal microbiome data significantly, although not as strongly as CVID diagnosis in bacterial assessment. Overall, our results suggest that gut bacterial microbiota is altered in CVID patients and may be one of the missing environmental drivers contributing to some of the symptoms and disease severity. Paired samples serving as controls will provide a better resolution between disease-related dysbiosis and other environmental confounders in future studies.
ER -
FIEDOROVÁ, Kristýna, Matěj RADVANSKÝ, Juraj BOSÁK, Hana GROMBIŘÍKOVÁ, Eva NĚMCOVÁ, Pavlina KRÁLÍČKOVÁ, Michaela ČERNOCHOVÁ, Iva KOTÁSKOVÁ, Matej LEXA, Jiří LITZMAN, David ŠMAJS and Tomáš FREIBERGER. Bacterial but Not Fungal Gut Microbiota Alterations Are Associated With Common Variable Immunodeficiency (CVID) Phenotype. \textit{Frontiers in Immunology}. LAUSANNE: FRONTIERS MEDIA SA, 2019, vol.~10, No~1914, p.~1-14. ISSN~1664-3224. Available from: https://dx.doi.org/10.3389/fimmu.2019.01914.
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