MicroRNA-15b-5p Predicts Locoregional Relapse in Head and Neck
Carcinoma Patients Treated With Intensity-modulated
Radiotherapy

J 2019

MicroRNA-15b-5p Predicts Locoregional Relapse in Head and Neck Carcinoma Patients Treated With Intensity-modulated Radiotherapy

AHMAD, Parwez, Jiří ŠÁNA, Marek SLÁVIK, Dominik GURÍN, Lenka RADOVÁ et. al.

Basic information

Original name

MicroRNA-15b-5p Predicts Locoregional Relapse in Head and Neck Carcinoma Patients Treated With Intensity-modulated Radiotherapy

Authors

AHMAD, Parwez (356 India, belonging to the institution), Jiří ŠÁNA (203 Czech Republic, belonging to the institution), Marek SLÁVIK (703 Slovakia, belonging to the institution), Dominik GURÍN (203 Czech Republic, belonging to the institution), Lenka RADOVÁ (203 Czech Republic, belonging to the institution), Natalia Anna GABŁO (616 Poland, belonging to the institution), Tomáš KAZDA (203 Czech Republic, belonging to the institution), Pavel SMILEK (203 Czech Republic, belonging to the institution), Zuzana HORÁKOVÁ (203 Czech Republic, belonging to the institution), Břetislav GÁL (203 Czech Republic, belonging to the institution), Markéta HERMANOVÁ (203 Czech Republic, belonging to the institution), Pavel ŠLAMPA (203 Czech Republic, belonging to the institution) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution)

Edition

CANCER GENOMICS & PROTEOMICS, ATHENS, INT INST ANTICANCER RESEARCH, 2019, 1109-6535

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Greece

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.280

RIV identification code

RIV/00216224:14740/19:00108511

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.21873/cgp.20119

UT WoS

000463451200004

Keywords in English

Head and neck cancer; microRNA; miR-15b-5p; locoregional control; radiotherapy; IMRT

Abstract

V originále

Background/Aim: Head and neck cancers are a heterogenous group of epithelial tumors represented mainly by squamous cell carcinomas (HNSCC), which are the sixth most common type of cancer worldwide. Surgery together with radiotherapy (RT) is among the basic treatment modalities for most HNSCC patients. Various biomarkers aiming to predict patients' response to RT are currently investigated. The reason behind this effort is, on one hand, to distinguish radioresistant patients that show weak benefit from RT and, on the other hand, reduce the ionizing radiation dose in less aggressive radiosensitive HNSCC with possibly less acute or late toxicity. Materials and Methods: A total of 94 HNSCC patients treated by definitive intensity-modulated radiotherapy were included in our retrospective study. We used a global expression analysis of microRNAs (miRNAs) in 43 tumor samples and validated a series of selected miRNAs in an independent set of 51 tumors. Results: We identified miR-15b-5p to be differentially expressed between patients with short and long time of locoregional control (LRC). Kaplan-Meier analysis confirmed that HNSCC patients with higher expression of miR-15b-5p reach a significantly longer locoregional relapsefree survival compared to patients expressing low levels. Finally, multivariable Cox regression analysis revealed that miR-15b-5p is an independent predictive biomarker of LRC in HNSCC patients (HR=0.25 ; 95% CI=0.05-0.78; p<0.016). Conclusion: miR-15b-5p represents a potentially helpful biomarker for individualized treatment decisions concerning the management of HNSCC patients.

Links

NV15-31627A, research and development project

Name: Možnosti molekulárně řízené radikální radioterapie nebo radiochemoterapie dle profilu mikroRNA u pacientů se spinocelulárními karcinomy hlavy a krku.

Citovat

AHMAD, Parwez, Jiří ŠÁNA, Marek SLÁVIK, Dominik GURÍN, Lenka RADOVÁ, Natalia Anna GABŁO, Tomáš KAZDA, Pavel SMILEK, Zuzana HORÁKOVÁ, Břetislav GÁL, Markéta HERMANOVÁ, Pavel ŠLAMPA and Ondřej SLABÝ. MicroRNA-15b-5p Predicts Locoregional Relapse in Head and Neck Carcinoma Patients Treated With Intensity-modulated Radiotherapy. CANCER GENOMICS & PROTEOMICS. ATHENS: INT INST ANTICANCER RESEARCH, 2019, vol. 16, No 2, p. 139-146. ISSN 1109-6535. Available from: https://dx.doi.org/10.21873/cgp.20119.

@article{1555278,
   author = {Ahmad, Parwez and Šána, Jiří and Slávik, Marek and Gurín, Dominik and Radová, Lenka and Gabło, Natalia Anna and Kazda, Tomáš and Smilek, Pavel and Horáková, Zuzana and Gál, Břetislav and Hermanová, Markéta and Šlampa, Pavel and Slabý, Ondřej},
   article_location = {ATHENS},
   article_number = {2},
   doi = {http://dx.doi.org/10.21873/cgp.20119},
   keywords = {Head and neck cancer; microRNA; miR-15b-5p; locoregional control; radiotherapy; IMRT},
   language = {eng},
   issn = {1109-6535},
   journal = {CANCER GENOMICS & PROTEOMICS},
   title = {MicroRNA-15b-5p Predicts Locoregional Relapse in Head and Neck Carcinoma Patients Treated With Intensity-modulated Radiotherapy},
   url = {http://cgp.iiarjournals.org/content/16/2/139.full.pdf},
   volume = {16},
   year = {2019}
}

TY  - JOUR
ID  - 1555278
AU  - Ahmad, Parwez - Šána, Jiří - Slávik, Marek - Gurín, Dominik - Radová, Lenka - Gabło, Natalia Anna - Kazda, Tomáš - Smilek, Pavel - Horáková, Zuzana - Gál, Břetislav - Hermanová, Markéta - Šlampa, Pavel - Slabý, Ondřej
PY  - 2019
TI  - MicroRNA-15b-5p Predicts Locoregional Relapse in Head and Neck Carcinoma Patients Treated With Intensity-modulated Radiotherapy
JF  - CANCER GENOMICS & PROTEOMICS
VL  - 16
IS  - 2
SP  - 139-146
EP  - 139-146
PB  - INT INST ANTICANCER RESEARCH
SN  - 11096535
KW  - Head and neck cancer
KW  - microRNA
KW  - miR-15b-5p
KW  - locoregional control
KW  - radiotherapy
KW  - IMRT
UR  - http://cgp.iiarjournals.org/content/16/2/139.full.pdf
L2  - http://cgp.iiarjournals.org/content/16/2/139.full.pdf
N2  - Background/Aim: Head and neck cancers are a heterogenous group of epithelial tumors represented mainly by squamous cell carcinomas (HNSCC), which are the sixth most common type of cancer worldwide. Surgery together with radiotherapy (RT) is among the basic treatment modalities for most HNSCC patients. Various biomarkers aiming to predict patients' response to RT are currently investigated. The reason behind this effort is, on one hand, to distinguish radioresistant patients that show weak benefit from RT and, on the other hand, reduce the ionizing radiation dose in less aggressive radiosensitive HNSCC with possibly less acute or late toxicity. Materials and Methods: A total of 94 HNSCC patients treated by definitive intensity-modulated radiotherapy were included in our retrospective study. We used a global expression analysis of microRNAs (miRNAs) in 43 tumor samples and validated a series of selected miRNAs in an independent set of 51 tumors. Results: We identified miR-15b-5p to be differentially expressed between patients with short and long time of locoregional control (LRC). Kaplan-Meier analysis confirmed that HNSCC patients with higher expression of miR-15b-5p reach a significantly longer locoregional relapsefree survival compared to patients expressing low levels. Finally, multivariable Cox regression analysis revealed that miR-15b-5p is an independent predictive biomarker of LRC in HNSCC patients (HR=0.25 ; 95% CI=0.05-0.78; p<0.016). Conclusion: miR-15b-5p represents a potentially helpful biomarker for individualized treatment decisions concerning the management of HNSCC patients.
ER  -

AHMAD, Parwez, Jiří ŠÁNA, Marek SLÁVIK, Dominik GURÍN, Lenka RADOVÁ, Natalia Anna GABŁO, Tomáš KAZDA, Pavel SMILEK, Zuzana HORÁKOVÁ, Břetislav GÁL, Markéta HERMANOVÁ, Pavel ŠLAMPA and Ondřej SLABÝ. MicroRNA-15b-5p Predicts Locoregional Relapse in Head and Neck Carcinoma Patients Treated With Intensity-modulated Radiotherapy. \textit{CANCER GENOMICS \&{}amp; PROTEOMICS}. ATHENS: INT INST ANTICANCER RESEARCH, 2019, vol.~16, No~2, p.~139-146. ISSN~1109-6535. Available from: https://dx.doi.org/10.21873/cgp.20119.

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