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@article{1557556,
author = {Arab, Anas and Rudá, Jana and Minsterová, Alžběta and Dražanová, Eva and Szabó, Nikoletta and Starčuk, Zenon and Rektorová, Irena and Khairnar, Amit Suresh},
article_location = {New York},
article_number = {4},
doi = {http://dx.doi.org/10.1007/s12640-019-00068-0},
keywords = {Behaviour; Diffusion kurtosis imaging; MRI; Methamphetamine; Mice; Parkinson’s disease; Tract-based spatial statistics},
language = {eng},
issn = {1029-8428},
journal = {Neurotoxicity research},
title = {Diffusion Kurtosis Imaging Detects Microstructural Changes in a Methamphetamine-Induced Mouse Model of Parkinson's Disease.},
url = {https://link.springer.com/article/10.1007%2Fs12640-019-00068-0},
volume = {36},
year = {2019}
}
TY - JOUR
ID - 1557556
AU - Arab, Anas - Rudá, Jana - Minsterová, Alžběta - Dražanová, Eva - Szabó, Nikoletta - Starčuk, Zenon - Rektorová, Irena - Khairnar, Amit Suresh
PY - 2019
TI - Diffusion Kurtosis Imaging Detects Microstructural Changes in a Methamphetamine-Induced Mouse Model of Parkinson's Disease.
JF - Neurotoxicity research
VL - 36
IS - 4
SP - 724-735
EP - 724-735
PB - Springer
SN - 10298428
KW - Behaviour
KW - Diffusion kurtosis imaging
KW - MRI
KW - Methamphetamine
KW - Mice
KW - Parkinson’s disease
KW - Tract-based spatial statistics
UR - https://link.springer.com/article/10.1007%2Fs12640-019-00068-0
L2 - https://link.springer.com/article/10.1007%2Fs12640-019-00068-0
N2 - Methamphetamine (METH) abuse is known to increase the risk of Parkinson's disease (PD) due to its dopaminergic neurotoxicity. This is the rationale for the METH model of PD developed by toxic METH dosing (10 mg/kg four times every 2 h) which features robust neurodegeneration and typical motor impairment in mice. In this study, we used diffusion kurtosis imaging to reveal microstructural brain changes caused by METH-induced neurodegeneration. The METH-treated mice and saline-treated controls underwent diffusion kurtosis imaging scanning using the Bruker Avance 9.4 Tesla MRI system at two time-points: 5 days and 1 month to capture both early and late changes induced by METH. At 5 days, we found a decrease in kurtosis in substantia nigra, striatum and sensorimotor cortex, which is likely to indicate loss of DAergic neurons. At 1 month, we found an increase of kurtosis in striatum and sensorimotor cortex and hippocampus, which may reflect certain recovery processes. Furthermore, we performed tract-based spatial statistics analysis in the white matter and at 1 month, we observed increased kurtosis in ventral nucleus of the lateral lemniscus and some of the lateral thalamic nuclei. No changes were present at the early stage. This study confirms the ability of diffusion kurtosis imaging to detect microstructural pathological processes in both grey and white matter in the METH model of PD. The exact mechanisms underlying the kurtosis changes remain to be elucidated but kurtosis seems to be a valuable biomarker for tracking microstructural brain changes in PD and potentially other neurodegenerative disorders.
ER -
ARAB, Anas, Jana RUDÁ, Alžběta MINSTEROVÁ, Eva DRAŽANOVÁ, Nikoletta SZABÓ, Zenon STARČUK, Irena REKTOROVÁ and Amit Suresh KHAIRNAR. Diffusion Kurtosis Imaging Detects Microstructural Changes in a Methamphetamine-Induced Mouse Model of Parkinson's Disease. \textit{Neurotoxicity research}. New York: Springer, 2019, vol.~36, No~4, p.~724-735. ISSN~1029-8428. Available from: https://dx.doi.org/10.1007/s12640-019-00068-0.
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