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@proceedings{1558556, author = {Chocholová, Eva and Drozdová, Eva and Fialová, Dana and Brzobohatá, Kristýna and Chochola, Václav}, booktitle = {6th International Anthropological Congress of Dr. Aleš Hrdlička}, keywords = {pathogen; ancient DNA; aDNA; tuberculosis; MTBC; IS6110}, language = {eng}, title = {Need for novel detection targets in tuberculosis diagnostics of historical specimens - bioinformatic analysis}, url = {http://www.pojivo.cz/pu/PU-2019-Suppl-2--Humpolec-190830.pdf}, year = {2019} }
TY - CONF ID - 1558556 AU - Chocholová, Eva - Drozdová, Eva - Fialová, Dana - Brzobohatá, Kristýna - Chochola, Václav PY - 2019 TI - Need for novel detection targets in tuberculosis diagnostics of historical specimens - bioinformatic analysis KW - pathogen KW - ancient DNA KW - aDNA KW - tuberculosis KW - MTBC KW - IS6110 UR - http://www.pojivo.cz/pu/PU-2019-Suppl-2--Humpolec-190830.pdf L2 - http://www.pojivo.cz/pu/PU-2019-Suppl-2--Humpolec-190830.pdf N2 - Diagnosis of tuberculosis from historical specimens has been mostly based on detection of IS6110 by PCR and following gel electrophoresis. Even when some authors stressed the possibility that this insertion sequence may have similar counterparts in other microorganisms (e.g. soil bacteria), it continued to be used widely, sometimes without sequencing of the PCR product. This work is aiming at IS6110 and two other sequences that are potential targets for DNA detection of Mycobacteria tuberculosis complex. These three loci are compared by bioinformatic and phylogenetic analysis to assess their usability in ancient DNA studies. ER -
CHOCHOLOVÁ, Eva, Eva DROZDOVÁ, Dana FIALOVÁ, Kristýna BRZOBOHATÁ and Václav CHOCHOLA. Need for novel detection targets in tuberculosis diagnostics of historical specimens - bioinformatic analysis. In \textit{6th International Anthropological Congress of Dr. Aleš Hrdlička}. 2019. ISSN~2336-4777.
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