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@article{1561417,
author = {Konečná, Klára and Lyčka, Martin and Nohelová, Lucie and Petráková, Monika and Fňašková, Monika and Koriťáková, Eva and Sováková, Pavla and Brabencová, Sylva and Preiss, Marek and Rektor, Ivan and Fajkus, Jiří and Fojtová, Miloslava},
article_number = {OCT 2019},
doi = {http://dx.doi.org/10.1016/j.jpsychires.2019.06.018},
keywords = {Telomere; Holocaust; stress; quantitative PCR},
language = {eng},
issn = {0022-3956},
journal = {Journal of Psychiatric Research},
title = {Holocaust history is not reflected in telomere homeostasis in survivors and their offspring},
url = {http://www.ncbi.nlm.nih.gov/pubmed/31255955},
volume = {117},
year = {2019}
}
TY - JOUR
ID - 1561417
AU - Konečná, Klára - Lyčka, Martin - Nohelová, Lucie - Petráková, Monika - Fňašková, Monika - Koriťáková, Eva - Sováková, Pavla - Brabencová, Sylva - Preiss, Marek - Rektor, Ivan - Fajkus, Jiří - Fojtová, Miloslava
PY - 2019
TI - Holocaust history is not reflected in telomere homeostasis in survivors and their offspring
JF - Journal of Psychiatric Research
VL - 117
IS - OCT 2019
SP - 7-14
EP - 7-14
PB - Elsevier
SN - 00223956
KW - Telomere
KW - Holocaust
KW - stress
KW - quantitative PCR
UR - http://www.ncbi.nlm.nih.gov/pubmed/31255955
L2 - http://www.ncbi.nlm.nih.gov/pubmed/31255955
N2 - Telomeres, nucleoprotein structures at the ends of eukaryotic chromosomes, are crucial for the maintenance of genome integrity. While the lengths of telomeres at birth are determined genetically, many factors including environmental and living conditions affect the telomere lengths during a lifespan. In this context, extreme and long-term stress has been shown to negatively impact telomeres and their protective function, with even offspring being influenced by the stress experienced by parents. Using quantitative PCR, the relative lengths of telomeres of survivors of the Holocaust during World War II and two generations of their offspring were analyzed. These data were related to those of control groups, persons of comparable age without a strong life stress experience. In contrast to previous studies of other stress-exposed groups, the relative lengths of telomeres were comparable in groups of persons exposed to Holocaust-related stress and their progenies, and in control groups. Interestingly, shorter telomeres of Holocaust survivors of the age under 12 in the year 1945 compared to Holocaust survivors of the age above 12 were detected. Our results are discussed with respect to certain exceptionality of persons having been able to cope with an extreme stress more than 70 years ago and living to a very old age.
ER -
KONEČNÁ, Klára, Martin LYČKA, Lucie NOHELOVÁ, Monika PETRÁKOVÁ, Monika FŇAŠKOVÁ, Eva KORIŤÁKOVÁ, Pavla SOVÁKOVÁ, Sylva BRABENCOVÁ, Marek PREISS, Ivan REKTOR, Jiří FAJKUS a Miloslava FOJTOVÁ. Holocaust history is not reflected in telomere homeostasis in survivors and their offspring. \textit{Journal of Psychiatric Research}. Elsevier, roč.~117, OCT 2019, s.~7-14. ISSN~0022-3956. doi:10.1016/j.jpsychires.2019.06.018. 2019.
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