Holocaust history is not reflected in telomere homeostasis in
survivors and their offspring

J 2019

Holocaust history is not reflected in telomere homeostasis in survivors and their offspring

KONEČNÁ, Klára, Martin LYČKA, Lucie NOHELOVÁ, Monika PETRÁKOVÁ, Monika FŇAŠKOVÁ et. al.

Basic information

Original name

Holocaust history is not reflected in telomere homeostasis in survivors and their offspring

Authors

KONEČNÁ, Klára (203 Czech Republic, belonging to the institution), Martin LYČKA (203 Czech Republic, belonging to the institution), Lucie NOHELOVÁ (203 Czech Republic, belonging to the institution), Monika PETRÁKOVÁ (203 Czech Republic, belonging to the institution), Monika FŇAŠKOVÁ (203 Czech Republic, belonging to the institution), Eva KORIŤÁKOVÁ (203 Czech Republic, belonging to the institution), Pavla SOVÁKOVÁ (203 Czech Republic, belonging to the institution), Sylva BRABENCOVÁ (203 Czech Republic, belonging to the institution), Marek PREISS (203 Czech Republic, belonging to the institution), Ivan REKTOR (203 Czech Republic, belonging to the institution), Jiří FAJKUS (203 Czech Republic, belonging to the institution) and Miloslava FOJTOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of Psychiatric Research, Elsevier, 2019, 0022-3956

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30101 Human genetics

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Stránka publikace na PubMed

Impact factor

Impact factor: 3.745

RIV identification code

RIV/00216224:14740/19:00108514

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1016/j.jpsychires.2019.06.018

UT WoS

000484872500002

Keywords in English

Telomere; Holocaust; stress; quantitative PCR

Abstract

V originále

Telomeres, nucleoprotein structures at the ends of eukaryotic chromosomes, are crucial for the maintenance of genome integrity. While the lengths of telomeres at birth are determined genetically, many factors including environmental and living conditions affect the telomere lengths during a lifespan. In this context, extreme and long-term stress has been shown to negatively impact telomeres and their protective function, with even offspring being influenced by the stress experienced by parents. Using quantitative PCR, the relative lengths of telomeres of survivors of the Holocaust during World War II and two generations of their offspring were analyzed. These data were related to those of control groups, persons of comparable age without a strong life stress experience. In contrast to previous studies of other stress-exposed groups, the relative lengths of telomeres were comparable in groups of persons exposed to Holocaust-related stress and their progenies, and in control groups. Interestingly, shorter telomeres of Holocaust survivors of the age under 12 in the year 1945 compared to Holocaust survivors of the age above 12 were detected. Our results are discussed with respect to certain exceptionality of persons having been able to cope with an extreme stress more than 70 years ago and living to a very old age.

Links

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

NV18-04-00559, research and development project

Name: Neurobiologické a psychologické markery reakce na extrémní stres a jeho dopad na potomky - třígenerační studie přeživších holokaust a jejich potomků

Investor: Ministry of Health of the CR, Neurobiological and psychological markers of reaction to extreme stress and its impact on offspring - three generation study of holocaust survivors and their offspring

Citovat

KONEČNÁ, Klára, Martin LYČKA, Lucie NOHELOVÁ, Monika PETRÁKOVÁ, Monika FŇAŠKOVÁ, Eva KORIŤÁKOVÁ, Pavla SOVÁKOVÁ, Sylva BRABENCOVÁ, Marek PREISS, Ivan REKTOR, Jiří FAJKUS and Miloslava FOJTOVÁ. Holocaust history is not reflected in telomere homeostasis in survivors and their offspring. Journal of Psychiatric Research. Elsevier, 2019, vol. 117, OCT 2019, p. 7-14. ISSN 0022-3956. Available from: https://dx.doi.org/10.1016/j.jpsychires.2019.06.018.

@article{1561417,
   author = {Konečná, Klára and Lyčka, Martin and Nohelová, Lucie and Petráková, Monika and Fňašková, Monika and Koriťáková, Eva and Sováková, Pavla and Brabencová, Sylva and Preiss, Marek and Rektor, Ivan and Fajkus, Jiří and Fojtová, Miloslava},
   article_number = {OCT 2019},
   doi = {http://dx.doi.org/10.1016/j.jpsychires.2019.06.018},
   keywords = {Telomere; Holocaust; stress; quantitative PCR},
   language = {eng},
   issn = {0022-3956},
   journal = {Journal of Psychiatric Research},
   title = {Holocaust history is not reflected in telomere homeostasis in survivors and their offspring},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/31255955},
   volume = {117},
   year = {2019}
}

TY  - JOUR
ID  - 1561417
AU  - Konečná, Klára - Lyčka, Martin - Nohelová, Lucie - Petráková, Monika - Fňašková, Monika - Koriťáková, Eva - Sováková, Pavla - Brabencová, Sylva - Preiss, Marek - Rektor, Ivan - Fajkus, Jiří - Fojtová, Miloslava
PY  - 2019
TI  - Holocaust history is not reflected in telomere homeostasis in survivors and their offspring
JF  - Journal of Psychiatric Research
VL  - 117
IS  - OCT 2019
SP  - 7-14
EP  - 7-14
PB  - Elsevier
SN  - 00223956
KW  - Telomere
KW  - Holocaust
KW  - stress
KW  - quantitative PCR
UR  - http://www.ncbi.nlm.nih.gov/pubmed/31255955
L2  - http://www.ncbi.nlm.nih.gov/pubmed/31255955
N2  - Telomeres, nucleoprotein structures at the ends of eukaryotic chromosomes, are crucial for the maintenance of genome integrity. While the lengths of telomeres at birth are determined genetically, many factors including environmental and living conditions affect the telomere lengths during a lifespan. In this context, extreme and long-term stress has been shown to negatively impact telomeres and their protective function, with even offspring being influenced by the stress experienced by parents. Using quantitative PCR, the relative lengths of telomeres of survivors of the Holocaust during World War II and two generations of their offspring were analyzed. These data were related to those of control groups, persons of comparable age without a strong life stress experience. In contrast to previous studies of other stress-exposed groups, the relative lengths of telomeres were comparable in groups of persons exposed to Holocaust-related stress and their progenies, and in control groups. Interestingly, shorter telomeres of Holocaust survivors of the age under 12 in the year 1945 compared to Holocaust survivors of the age above 12 were detected. Our results are discussed with respect to certain exceptionality of persons having been able to cope with an extreme stress more than 70 years ago and living to a very old age.
ER  -

KONEČNÁ, Klára, Martin LYČKA, Lucie NOHELOVÁ, Monika PETRÁKOVÁ, Monika FŇAŠKOVÁ, Eva KORIŤÁKOVÁ, Pavla SOVÁKOVÁ, Sylva BRABENCOVÁ, Marek PREISS, Ivan REKTOR, Jiří FAJKUS and Miloslava FOJTOVÁ. Holocaust history is not reflected in telomere homeostasis in survivors and their offspring. \textit{Journal of Psychiatric Research}. Elsevier, 2019, vol.~117, OCT 2019, p.~7-14. ISSN~0022-3956. Available from: https://dx.doi.org/10.1016/j.jpsychires.2019.06.018.

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