Joint adolescent-adult early phase clinical trials to improve
access to new drugs for adolescents with cancer: proposals from
the multi-stakeholder platform-ACCELERATE

J 2018

Joint adolescent-adult early phase clinical trials to improve access to new drugs for adolescents with cancer: proposals from the multi-stakeholder platform-ACCELERATE

GASPAR, N., L.V. MARSHALL, D. BINNER, R. HEROLD, R. ROUSSEAU et. al.

Basic information

Original name

Joint adolescent-adult early phase clinical trials to improve access to new drugs for adolescents with cancer: proposals from the multi-stakeholder platform-ACCELERATE

Authors

GASPAR, N. (250 France, guarantor), L.V. MARSHALL (826 United Kingdom of Great Britain and Northern Ireland), D. BINNER (826 United Kingdom of Great Britain and Northern Ireland), R. HEROLD (826 United Kingdom of Great Britain and Northern Ireland), R. ROUSSEAU (840 United States of America), P. BLANC (250 France), R. CAPDEVILLE (756 Switzerland), J. CARLEER (56 Belgium), C. COPLAND (826 United Kingdom of Great Britain and Northern Ireland), Y. KERLOEGUEN (756 Switzerland), K. NORGA (56 Belgium), L. PACAUD (756 Switzerland), M.A. SEVAUX (250 France), C. SPADONI (826 United Kingdom of Great Britain and Northern Ireland), Jaroslav ŠTĚRBA (203 Czech Republic, belonging to the institution), F. LIGAS (826 United Kingdom of Great Britain and Northern Ireland), T. TAUBE (276 Germany), M. UTTENREUTHER-FISCHER (276 Germany), S. CHIOATO (380 Italy), M.A. O'CONNELL (380 Italy), B. GEOERGER (250 France), J.Y. BLAY (250 France), J.C. SORIA (380 Italy), S. KAYE (826 United Kingdom of Great Britain and Northern Ireland), B. WULFF (276 Germany), L. BRUGIERES (380 Italy), G. VASSAL (250 France) and ADJ PEARSON (826 United Kingdom of Great Britain and Northern Ireland)

Edition

Annals of Oncology, OXFORD, Oxford University Press, 2018, 0923-7534

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 14.196

RIV identification code

RIV/00216224:14110/18:00108516

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1093/annonc/mdy002

UT WoS

000429455000036

Keywords in English

PEDIATRIC-PATIENTS; HODGKINS-LYMPHOMA; SOLID TUMORS; YOUNG-ADULTS; ONCOLOGY; CHILDREN; PARTICIPATION; APPROPRIATE; TEENAGERS; RECURRENT

Abstract

V originále

The impressive progress recently observed in adult cancers through the introduction of new drugs has not yet been translated to adolescents 12-17 years of age [defined according to the International Conference on Harmonization (ICH) E11]. The current drug development landscape separates adult and paediatric drug development (Table 1). Adolescents are grouped with children, leading to a mismatch with a lack of trials for adolescents with relapsed cancer and delayed access to new, effective drugs already available for adults.

Links

NV16-33209A, research and development project

Name: Sekvenování nové generace a expresní profilování jako diagnostický podklad pro návrhy individualizovaných léčebných plánů pro děti se solidními nádory

NV16-34083A, research and development project

Name: Receptorové tyrozinkinázy a navazující signální dráhy jako potenciální cíle léčby refrakterních solidních nádorů dětského věku

Citovat

GASPAR, N., L.V. MARSHALL, D. BINNER, R. HEROLD, R. ROUSSEAU, P. BLANC, R. CAPDEVILLE, J. CARLEER, C. COPLAND, Y. KERLOEGUEN, K. NORGA, L. PACAUD, M.A. SEVAUX, C. SPADONI, Jaroslav ŠTĚRBA, F. LIGAS, T. TAUBE, M. UTTENREUTHER-FISCHER, S. CHIOATO, M.A. O'CONNELL, B. GEOERGER, J.Y. BLAY, J.C. SORIA, S. KAYE, B. WULFF, L. BRUGIERES, G. VASSAL and ADJ PEARSON. Joint adolescent-adult early phase clinical trials to improve access to new drugs for adolescents with cancer: proposals from the multi-stakeholder platform-ACCELERATE. Annals of Oncology. OXFORD: Oxford University Press, 2018, vol. 29, No 3, p. 766-771. ISSN 0923-7534. Available from: https://dx.doi.org/10.1093/annonc/mdy002.

@article{1565258,
   author = {Gaspar, N. and Marshall, L.V. and Binner, D. and Herold, R. and Rousseau, R. and Blanc, P. and Capdeville, R. and Carleer, J. and Copland, C. and Kerloeguen, Y. and Norga, K. and Pacaud, L. and Sevaux, M.A. and Spadoni, C. and Štěrba, Jaroslav and Ligas, F. and Taube, T. and UttenreutherandFischer, M. and Chioato, S. and O'Connell, M.A. and Geoerger, B. and Blay, J.Y. and Soria, J.C. and Kaye, S. and Wulff, B. and Brugieres, L. and Vassal, G. and Pearson, ADJ},
   article_location = {OXFORD},
   article_number = {3},
   doi = {http://dx.doi.org/10.1093/annonc/mdy002},
   keywords = {PEDIATRIC-PATIENTS; HODGKINS-LYMPHOMA; SOLID TUMORS; YOUNG-ADULTS; ONCOLOGY; CHILDREN; PARTICIPATION; APPROPRIATE; TEENAGERS; RECURRENT},
   language = {eng},
   issn = {0923-7534},
   journal = {Annals of Oncology},
   title = {Joint adolescent-adult early phase clinical trials to improve access to new drugs for adolescents with cancer: proposals from the multi-stakeholder platform-ACCELERATE},
   url = {http://dx.doi.org/10.1093/annonc/mdy002},
   volume = {29},
   year = {2018}
}

TY  - JOUR
ID  - 1565258
AU  - Gaspar, N. - Marshall, L.V. - Binner, D. - Herold, R. - Rousseau, R. - Blanc, P. - Capdeville, R. - Carleer, J. - Copland, C. - Kerloeguen, Y. - Norga, K. - Pacaud, L. - Sevaux, M.A. - Spadoni, C. - Štěrba, Jaroslav - Ligas, F. - Taube, T. - Uttenreuther-Fischer, M. - Chioato, S. - O'Connell, M.A. - Geoerger, B. - Blay, J.Y. - Soria, J.C. - Kaye, S. - Wulff, B. - Brugieres, L. - Vassal, G. - Pearson, ADJ
PY  - 2018
TI  - Joint adolescent-adult early phase clinical trials to improve access to new drugs for adolescents with cancer: proposals from the multi-stakeholder platform-ACCELERATE
JF  - Annals of Oncology
VL  - 29
IS  - 3
SP  - 766-771
EP  - 766-771
PB  - Oxford University Press
SN  - 09237534
KW  - PEDIATRIC-PATIENTS
KW  - HODGKINS-LYMPHOMA
KW  - SOLID TUMORS
KW  - YOUNG-ADULTS
KW  - ONCOLOGY
KW  - CHILDREN
KW  - PARTICIPATION
KW  - APPROPRIATE
KW  - TEENAGERS
KW  - RECURRENT
UR  - http://dx.doi.org/10.1093/annonc/mdy002
L2  - http://dx.doi.org/10.1093/annonc/mdy002
N2  - The impressive progress recently observed in adult cancers through the introduction of new drugs has not yet been translated to adolescents 12-17 years of age [defined according to the International Conference on Harmonization (ICH) E11]. The current drug development landscape separates adult and paediatric drug development (Table 1). Adolescents are grouped with children, leading to a mismatch with a lack of trials for adolescents with relapsed cancer and delayed access to new, effective drugs already available for adults.
ER  -

GASPAR, N., L.V. MARSHALL, D. BINNER, R. HEROLD, R. ROUSSEAU, P. BLANC, R. CAPDEVILLE, J. CARLEER, C. COPLAND, Y. KERLOEGUEN, K. NORGA, L. PACAUD, M.A. SEVAUX, C. SPADONI, Jaroslav ŠTĚRBA, F. LIGAS, T. TAUBE, M. UTTENREUTHER-FISCHER, S. CHIOATO, M.A. O'CONNELL, B. GEOERGER, J.Y. BLAY, J.C. SORIA, S. KAYE, B. WULFF, L. BRUGIERES, G. VASSAL and ADJ PEARSON. Joint adolescent-adult early phase clinical trials to improve access to new drugs for adolescents with cancer: proposals from the multi-stakeholder platform-ACCELERATE. \textit{Annals of Oncology}. OXFORD: Oxford University Press, 2018, vol.~29, No~3, p.~766-771. ISSN~0923-7534. Available from: https://dx.doi.org/10.1093/annonc/mdy002.

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