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@article{1566136, author = {Havránková, Eva and Csöllei, Jozef and Pazdera, Pavel}, article_location = {Basel}, article_number = {19}, doi = {http://dx.doi.org/10.3390/molecules24193586}, keywords = {1 3 5-triazine; supported Cu(I) catalyst; Ullmann reaction; one-pot synthesis}, language = {eng}, issn = {1420-3049}, journal = {Molecules}, title = {New Approach for the One-Pot Synthesis of 1,3,5-Triazine Derivatives: Application of Cu(I) Supported on a Weakly Acidic Cation-Exchanger Resin in a Comparative Study}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804075/}, volume = {24}, year = {2019} }
TY - JOUR ID - 1566136 AU - Havránková, Eva - Csöllei, Jozef - Pazdera, Pavel PY - 2019 TI - New Approach for the One-Pot Synthesis of 1,3,5-Triazine Derivatives: Application of Cu(I) Supported on a Weakly Acidic Cation-Exchanger Resin in a Comparative Study JF - Molecules VL - 24 IS - 19 SP - 1-10 EP - 1-10 PB - MDPI SN - 14203049 KW - 1 3 5-triazine KW - supported Cu(I) catalyst KW - Ullmann reaction KW - one-pot synthesis UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804075/ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804075/ N2 - An efficient and simple methodology for Ullmann Cu(I)-catalyzed synthesis of di- and trisubstituted 1,3,5-triazine derivatives from dichlorotriazinyl benzenesulfonamide and corresponding nucleophiles is reported. Cations Cu(I) supported on macroporous and weakly acidic, low-cost industrial resin of polyacrylate type were used as a catalyst. The reaction times and yields were compared with traditional synthetic methods for synthesis of substituted 1,3,5-triazine derivatives via nucleophilic substitution of chlorine atoms in dichlorotriazinyl benzenesulfonamide. It was found that Ullmann-type reactions provide significantly shortened reaction times and, in some cases, also higher yields. Finally, trisubstituted s-triazine derivatives were effectively prepared via Ullmann-type reaction in a one-pot synthetic design. Six new s-triazine derivatives with potential biological activity were prepared and characterized. ER -
HAVRÁNKOVÁ, Eva, Jozef CSÖLLEI and Pavel PAZDERA. New Approach for the One-Pot Synthesis of 1,3,5-Triazine Derivatives: Application of Cu(I) Supported on a Weakly Acidic Cation-Exchanger Resin in a Comparative Study. \textit{Molecules}. Basel: MDPI, 2019, vol.~24, No~19, p.~1-10. ISSN~1420-3049. Available from: https://dx.doi.org/10.3390/molecules24193586.
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