HAVRÁNKOVÁ, Eva, Jozef CSÖLLEI and Pavel PAZDERA. New Approach for the One-Pot Synthesis of 1,3,5-Triazine Derivatives: Application of Cu(I) Supported on a Weakly Acidic Cation-Exchanger Resin in a Comparative Study. Molecules. Basel: MDPI, 2019, vol. 24, No 19, p. 1-10. ISSN 1420-3049. Available from: https://dx.doi.org/10.3390/molecules24193586.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name New Approach for the One-Pot Synthesis of 1,3,5-Triazine Derivatives: Application of Cu(I) Supported on a Weakly Acidic Cation-Exchanger Resin in a Comparative Study
Authors HAVRÁNKOVÁ, Eva (203 Czech Republic, belonging to the institution), Jozef CSÖLLEI (203 Czech Republic, belonging to the institution) and Pavel PAZDERA (203 Czech Republic, guarantor, belonging to the institution).
Edition Molecules, Basel, MDPI, 2019, 1420-3049.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10401 Organic chemistry
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
WWW Full Text
Impact factor Impact factor: 3.267
RIV identification code RIV/00216224:14310/19:00110875
Organization unit Faculty of Science
Doi http://dx.doi.org/10.3390/molecules24193586
UT WoS 000496242300171
Keywords in English 1 3 5-triazine; supported Cu(I) catalyst; Ullmann reaction; one-pot synthesis
Tags rivok, ÚChL
Tags International impact, Reviewed
Changed by Changed by: Mgr. Hana Hurtová, učo 244985. Changed: 3/3/2021 12:29.
Abstract
An efficient and simple methodology for Ullmann Cu(I)-catalyzed synthesis of di- and trisubstituted 1,3,5-triazine derivatives from dichlorotriazinyl benzenesulfonamide and corresponding nucleophiles is reported. Cations Cu(I) supported on macroporous and weakly acidic, low-cost industrial resin of polyacrylate type were used as a catalyst. The reaction times and yields were compared with traditional synthetic methods for synthesis of substituted 1,3,5-triazine derivatives via nucleophilic substitution of chlorine atoms in dichlorotriazinyl benzenesulfonamide. It was found that Ullmann-type reactions provide significantly shortened reaction times and, in some cases, also higher yields. Finally, trisubstituted s-triazine derivatives were effectively prepared via Ullmann-type reaction in a one-pot synthetic design. Six new s-triazine derivatives with potential biological activity were prepared and characterized.
PrintDisplayed: 4/9/2024 07:39