ANDRŠOVÁ, Irena, Katerina HNATKOVA, Kateřina HELÁNOVÁ, Martina ŠIŠÁKOVÁ, Tomáš NOVOTNÝ, Petr KALA and Marek MALIK. Individually Rate Corrected QTc Intervals in Children and Adolescents. Frontiers in Physiology. Lausanne: Frontiers Media, 2019, vol. 10, AUG 2 2019, p. 1-15. ISSN 1664-042X. Available from: https://dx.doi.org/10.3389/fphys.2019.00994.
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Basic information
Original name Individually Rate Corrected QTc Intervals in Children and Adolescents
Authors ANDRŠOVÁ, Irena (203 Czech Republic, belonging to the institution), Katerina HNATKOVA (826 United Kingdom of Great Britain and Northern Ireland), Kateřina HELÁNOVÁ (203 Czech Republic, belonging to the institution), Martina ŠIŠÁKOVÁ (203 Czech Republic, belonging to the institution), Tomáš NOVOTNÝ (203 Czech Republic, belonging to the institution), Petr KALA (203 Czech Republic, belonging to the institution) and Marek MALIK (826 United Kingdom of Great Britain and Northern Ireland, guarantor).
Edition Frontiers in Physiology, Lausanne, Frontiers Media, 2019, 1664-042X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 3.367
RIV identification code RIV/00216224:14110/19:00110888
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.3389/fphys.2019.00994
UT WoS 000478600700002
Keywords in English age; sex differences; individual QT/RR patterns; QT/RR hysteresis; QTc interval; QT/RR slope
Tags 14110211, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 8/10/2019 10:16.
Abstract
Accurate evaluation of the appearance of QTc sex differences during childhood and adolescence is intricate. Inter-subject differences of individual QT/RR patterns make generic heart rate corrections inaccurate because of fast resting heart rates in children. The study investigated 527 healthy children and adolescents aged 419 years (268 females, 50.9%). All underwent continuous ECG 12-lead monitoring while performing postural changes during a 70-min investigative protocol to obtain QT interval measurements at different heart rates. On average, more than 1200 ECG measurements (QT interval and its 5-min history of preceding RR intervals) were made in each subject. Curvilinear QT/RR regression involving intra-individual correction for QT/RR hysteresis were calculated in each subject. The projection of the QT/RR regressions to the heart rate of 60 beats per minute defined individually corrected QTc intervals. In males, gradual QTc shortening by about 15 ms appeared during the ages of 13-19 years synchronously with the incidence of secondary sex signs (p = 0.016). On the contrary, whilst gradual QTc prolongation by about 10 ms appeared in females, it occurred only during ages 16-19 years and was not related to the incidence of secondary sex signs (p = 0.18). The study also showed that in children and adolescents, linear QT/RR models fit the intra-subject data significantly more closely than the log-linear models (p < 0.001). The study speculates that hormonal shifts during puberty might be directly responsible for the QTc shortening in males but that QTc prolongation in females is likely more complex since it was noted to follow the appearance of secondary sex signs only after a considerable delay.
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