BÚTOVÁ, Romana, Petra VYCHYTILOVÁ-FALTEJSKOVA, Adéla SOUČKOVÁ, Sabina ŠEVČÍKOVÁ and Roman HÁJEK. Long Non-Coding RNAs in Multiple Myeloma. Non-coding RNA. Švýcarsko: MDPI, 2019, vol. 5, No 1, p. 1-15. ISSN 2311-553X. Available from: https://dx.doi.org/10.3390/ncrna5010013.
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Basic information
Original name Long Non-Coding RNAs in Multiple Myeloma
Authors BÚTOVÁ, Romana (703 Slovakia, belonging to the institution), Petra VYCHYTILOVÁ-FALTEJSKOVA (203 Czech Republic), Adéla SOUČKOVÁ (203 Czech Republic, belonging to the institution), Sabina ŠEVČÍKOVÁ (203 Czech Republic, guarantor, belonging to the institution) and Roman HÁJEK (203 Czech Republic).
Edition Non-coding RNA, Švýcarsko, MDPI, 2019, 2311-553X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30204 Oncology
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
WWW URL
RIV identification code RIV/00216224:14110/19:00108519
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.3390/ncrna5010013
UT WoS 000572582200001
Keywords in English Biomarker; Long non-coding RNAs; Multiple myeloma
Tags 14110518, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 23/8/2021 10:46.
Abstract
Multiple myeloma (MM) is the second most common hematooncological disease of malignant plasma cells in the bone marrow. While new treatment brought unprecedented increase of survival of patients, MM pathogenesis is yet to be clarified. Increasing evidence of expression of long non-coding RNA molecules (lncRNA) linked to development and progression of many tumors suggested their important role in tumorigenesis. To date, over 15,000 lncRNA molecules characterized by diversity of function and specificity of cell distribution were identified in the human genome. Due to their involvement in proliferation, apoptosis, metabolism, and differentiation, they have a key role in the biological processes and pathogenesis of many diseases, including MM. This review summarizes current knowledge of non-coding RNAs (ncRNA), especially lncRNAs, and their role in MM pathogenesis. Undeniable involvement of lncRNAs in MM development suggests their potential as biomarkers.
Links
NV17-29343A, research and development projectName: Analýza mikroprostředí kostní dřeně u extramedulárního relapsu mnohočetného myelomu
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