Long Non-Coding RNAs in Multiple Myeloma

J 2019

Long Non-Coding RNAs in Multiple Myeloma

BÚTOVÁ, Romana, Petra VYCHYTILOVÁ-FALTEJSKOVA, Adéla SOUČKOVÁ, Sabina ŠEVČÍKOVÁ, Roman HÁJEK et. al.

Basic information

Original name

Long Non-Coding RNAs in Multiple Myeloma

Authors

BÚTOVÁ, Romana (703 Slovakia, belonging to the institution), Petra VYCHYTILOVÁ-FALTEJSKOVA (203 Czech Republic), Adéla SOUČKOVÁ (203 Czech Republic, belonging to the institution), Sabina ŠEVČÍKOVÁ (203 Czech Republic, guarantor, belonging to the institution) and Roman HÁJEK (203 Czech Republic)

Edition

Non-coding RNA, Švýcarsko, MDPI, 2019, 2311-553X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

RIV identification code

RIV/00216224:14110/19:00108519

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/ncrna5010013

UT WoS

000572582200001

Keywords in English

Biomarker; Long non-coding RNAs; Multiple myeloma

Abstract

V originále

Multiple myeloma (MM) is the second most common hematooncological disease of malignant plasma cells in the bone marrow. While new treatment brought unprecedented increase of survival of patients, MM pathogenesis is yet to be clarified. Increasing evidence of expression of long non-coding RNA molecules (lncRNA) linked to development and progression of many tumors suggested their important role in tumorigenesis. To date, over 15,000 lncRNA molecules characterized by diversity of function and specificity of cell distribution were identified in the human genome. Due to their involvement in proliferation, apoptosis, metabolism, and differentiation, they have a key role in the biological processes and pathogenesis of many diseases, including MM. This review summarizes current knowledge of non-coding RNAs (ncRNA), especially lncRNAs, and their role in MM pathogenesis. Undeniable involvement of lncRNAs in MM development suggests their potential as biomarkers.

Links

NV17-29343A, research and development project

Name: Analýza mikroprostředí kostní dřeně u extramedulárního relapsu mnohočetného myelomu

Citovat

BÚTOVÁ, Romana, Petra VYCHYTILOVÁ-FALTEJSKOVA, Adéla SOUČKOVÁ, Sabina ŠEVČÍKOVÁ and Roman HÁJEK. Long Non-Coding RNAs in Multiple Myeloma. Non-coding RNA. Švýcarsko: MDPI, 2019, vol. 5, No 1, p. 1-15. ISSN 2311-553X. Available from: https://dx.doi.org/10.3390/ncrna5010013.

@article{1567317,
   author = {Bútová, Romana and VychytilováandFaltejskova, Petra and Součková, Adéla and Ševčíková, Sabina and Hájek, Roman},
   article_location = {Švýcarsko},
   article_number = {1},
   doi = {http://dx.doi.org/10.3390/ncrna5010013},
   keywords = {Biomarker; Long non-coding RNAs; Multiple myeloma},
   language = {eng},
   issn = {2311-553X},
   journal = {Non-coding RNA},
   title = {Long Non-Coding RNAs in Multiple Myeloma},
   url = {http://dx.doi.org/10.3390/ncrna5010013},
   volume = {5},
   year = {2019}
}

TY  - JOUR
ID  - 1567317
AU  - Bútová, Romana - Vychytilová-Faltejskova, Petra - Součková, Adéla - Ševčíková, Sabina - Hájek, Roman
PY  - 2019
TI  - Long Non-Coding RNAs in Multiple Myeloma
JF  - Non-coding RNA
VL  - 5
IS  - 1
SP  - 1-15
EP  - 1-15
PB  - MDPI
SN  - 2311553X
KW  - Biomarker
KW  - Long non-coding RNAs
KW  - Multiple myeloma
UR  - http://dx.doi.org/10.3390/ncrna5010013
L2  - http://dx.doi.org/10.3390/ncrna5010013
N2  - Multiple myeloma (MM) is the second most common hematooncological disease of malignant plasma cells in the bone marrow. While new treatment brought unprecedented increase of survival of patients, MM pathogenesis is yet to be clarified. Increasing evidence of expression of long non-coding RNA molecules (lncRNA) linked to development and progression of many tumors suggested their important role in tumorigenesis. To date, over 15,000 lncRNA molecules characterized by diversity of function and specificity of cell distribution were identified in the human genome. Due to their involvement in proliferation, apoptosis, metabolism, and differentiation, they have a key role in the biological processes and pathogenesis of many diseases, including MM. This review summarizes current knowledge of non-coding RNAs (ncRNA), especially lncRNAs, and their role in MM pathogenesis. Undeniable involvement of lncRNAs in MM development suggests their potential as biomarkers.
ER  -

BÚTOVÁ, Romana, Petra VYCHYTILOVÁ-FALTEJSKOVA, Adéla SOUČKOVÁ, Sabina ŠEVČÍKOVÁ and Roman HÁJEK. Long Non-Coding RNAs in Multiple Myeloma. \textit{Non-coding RNA}. Švýcarsko: MDPI, 2019, vol.~5, No~1, p.~1-15. ISSN~2311-553X. Available from: https://dx.doi.org/10.3390/ncrna5010013.

Detailed Information on Publication Record