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@article{1567317, author = {Bútová, Romana and VychytilováandFaltejskova, Petra and Součková, Adéla and Ševčíková, Sabina and Hájek, Roman}, article_location = {Švýcarsko}, article_number = {1}, doi = {http://dx.doi.org/10.3390/ncrna5010013}, keywords = {Biomarker; Long non-coding RNAs; Multiple myeloma}, language = {eng}, issn = {2311-553X}, journal = {Non-coding RNA}, title = {Long Non-Coding RNAs in Multiple Myeloma}, url = {http://dx.doi.org/10.3390/ncrna5010013}, volume = {5}, year = {2019} }
TY - JOUR ID - 1567317 AU - Bútová, Romana - Vychytilová-Faltejskova, Petra - Součková, Adéla - Ševčíková, Sabina - Hájek, Roman PY - 2019 TI - Long Non-Coding RNAs in Multiple Myeloma JF - Non-coding RNA VL - 5 IS - 1 SP - 1-15 EP - 1-15 PB - MDPI SN - 2311553X KW - Biomarker KW - Long non-coding RNAs KW - Multiple myeloma UR - http://dx.doi.org/10.3390/ncrna5010013 L2 - http://dx.doi.org/10.3390/ncrna5010013 N2 - Multiple myeloma (MM) is the second most common hematooncological disease of malignant plasma cells in the bone marrow. While new treatment brought unprecedented increase of survival of patients, MM pathogenesis is yet to be clarified. Increasing evidence of expression of long non-coding RNA molecules (lncRNA) linked to development and progression of many tumors suggested their important role in tumorigenesis. To date, over 15,000 lncRNA molecules characterized by diversity of function and specificity of cell distribution were identified in the human genome. Due to their involvement in proliferation, apoptosis, metabolism, and differentiation, they have a key role in the biological processes and pathogenesis of many diseases, including MM. This review summarizes current knowledge of non-coding RNAs (ncRNA), especially lncRNAs, and their role in MM pathogenesis. Undeniable involvement of lncRNAs in MM development suggests their potential as biomarkers. ER -
BÚTOVÁ, Romana, Petra VYCHYTILOVÁ-FALTEJSKOVA, Adéla SOUČKOVÁ, Sabina ŠEVČÍKOVÁ and Roman HÁJEK. Long Non-Coding RNAs in Multiple Myeloma. \textit{Non-coding RNA}. Švýcarsko: MDPI, 2019, vol.~5, No~1, p.~1-15. ISSN~2311-553X. Available from: https://dx.doi.org/10.3390/ncrna5010013.
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