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@article{1567478,
author = {Konig, Simone and Bayer, Malte and Dimova, Violeta and Herrnberger, Myriam and EscolanoandLozano, Fabiola and Bednařík, Josef and Vlčková, Eva and Rittner, Heike and Schlereth, Tanja and Birklein, Frank},
article_location = {New York},
article_number = {6},
doi = {http://dx.doi.org/10.1097/j.pain.0000000000001503},
keywords = {Complex regional pain syndrome; Chronic pain; Bradykinin; Serum peptidase},
language = {eng},
issn = {0304-3959},
journal = {Pain : the journal of the international association for the study of pain.},
title = {The serum protease network-one key to understand complex regional pain syndrome pathophysiology},
url = {http://dx.doi.org/10.1097/j.pain.0000000000001503},
volume = {160},
year = {2019}
}
TY - JOUR
ID - 1567478
AU - Konig, Simone - Bayer, Malte - Dimova, Violeta - Herrnberger, Myriam - Escolano-Lozano, Fabiola - Bednařík, Josef - Vlčková, Eva - Rittner, Heike - Schlereth, Tanja - Birklein, Frank
PY - 2019
TI - The serum protease network-one key to understand complex regional pain syndrome pathophysiology
JF - Pain : the journal of the international association for the study of pain.
VL - 160
IS - 6
SP - 1402-1409
EP - 1402-1409
PB - Elsevier
SN - 03043959
KW - Complex regional pain syndrome
KW - Chronic pain
KW - Bradykinin
KW - Serum peptidase
UR - http://dx.doi.org/10.1097/j.pain.0000000000001503
L2 - http://dx.doi.org/10.1097/j.pain.0000000000001503
N2 - Complex regional pain syndrome (CRPS) develops after fracture. The acute CRPS phenotype resembles exaggerated inflammation, which is explained by local and systemic activation of a proinflammatory network including peptides and cytokines. Epidemiologic data suggest that inactivation of the peptidase angiotensin-converting enzyme in patients treated for hypertension increases the odds to develop CRPS. This hint leads us to investigate the serum protease network activity in patients with CRPS vs respective controls. For this purpose, we developed a dabsyl-bradykinin (DBK)-based assay and used it to investigate patients with CRPS, as well as healthy and pain (painful diabetic neuropathy [dPNP]) controls. The major result is that the degradation of DBK to fragments 1-8 and 1-5 in healthy control and dPNP is shifted to higher values for DBK1-8 and lower values for DBK1-5 at 1 hour of incubation in patients with CRPS. Using this novel reporter peptide assay, we have been able to show that the resolving protease network for mediators such as BK might be different in patients with CRPS; having a look at the clinical signs, which resemble inflammation, this resolving protease network is probably less effective in CRPS.
ER -
KONIG, Simone, Malte BAYER, Violeta DIMOVA, Myriam HERRNBERGER, Fabiola ESCOLANO-LOZANO, Josef BEDNAŘÍK, Eva VLČKOVÁ, Heike RITTNER, Tanja SCHLERETH a Frank BIRKLEIN. The serum protease network-one key to understand complex regional pain syndrome pathophysiology. \textit{Pain : the journal of the international association for the study of pain.}. New York: Elsevier, roč.~160, č.~6, s.~1402-1409. ISSN~0304-3959. doi:10.1097/j.pain.0000000000001503. 2019.
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