Detailed Information on Publication Record
2019
Accuracy of Colon Capsule Endoscopy for Colorectal Neoplasia Detection in Individuals Referred for a Screening Colonoscopy
VOSKA, Michal, Miroslav ZAVORAL, Tomas GREGA, Ondřej MÁJEK, Jan MARTINEK et. al.Basic information
Original name
Accuracy of Colon Capsule Endoscopy for Colorectal Neoplasia Detection in Individuals Referred for a Screening Colonoscopy
Authors
VOSKA, Michal (203 Czech Republic), Miroslav ZAVORAL (203 Czech Republic), Tomas GREGA (203 Czech Republic), Ondřej MÁJEK (203 Czech Republic, belonging to the institution), Jan MARTINEK (203 Czech Republic), Ilja TACHECI (203 Czech Republic), Marek BENES (203 Czech Republic), Gabriela VOJTECHOVA (203 Czech Republic), Pavel DRASTICH (203 Czech Republic), Jan BURES (203 Czech Republic), Julius SPICAK (203 Czech Republic), Barbora BUČKOVÁ (703 Slovakia, belonging to the institution), Ondřej NGO (203 Czech Republic, belonging to the institution) and Stepan SUCHANEK (203 Czech Republic, guarantor)
Edition
Gastroenterology Research and Practice, New York, Hindawi Publishing Corporation, 2019, 1687-6121
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30219 Gastroenterology and hepatology
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 1.806
RIV identification code
RIV/00216224:14110/19:00108525
Organization unit
Faculty of Medicine
UT WoS
000486404300001
Keywords in English
Colon Capsule Endoscopy; Colorectal Neoplasia Detection; Screening
Tags
International impact, Reviewed
Změněno: 16/10/2019 15:49, Mgr. Tereza Miškechová
Abstract
V originále
Backround. Capsule colonoscopy might present an alternative to colonoscopy for colorectal neoplasia screening. Aim. To assess the accuracy of second-generation capsule colonoscopy (CCE2) for colorectal neoplasia detection compared with conventional colonoscopy (CC). Methods. From 2011-2015, we performed a multicenter, prospective, cross-over study evaluating the use of CCE2 as a possible colorectal cancer (CRC) screening test based on the assessment of the method's characteristics (accuracy) and safety and patient acceptance of the routine. Enrolled participants fulfilled the CRC screening population criteria if they were asymptomatic, were older than 50, and had no personal or familial history of colorectal neoplasia. The primary outcome was accuracy for the detection of polyps >= 6 mm. Secondary outcomes were accuracy for all polyps, polyps >= 10 mm, adenomas >= 10 mm, and cancers, the quality of bowel cleansing, safety, and CCE2 acceptability by the screening population. Results. A total of 236 individuals were examined; 11 patients (5%) were excluded. Therefore, 225 subjects (95%) were considered in the intention-to-screen (ITS) group. A total of 201 patients (89%) completed both examinations successfully (per protocol group). In the ITS group, polyps were diagnosed during CC in 114 subjects (51%); polyps >= 6 mm, polyps >= 10 mm, and adenomas >= 10 mm were diagnosed in 34 (15%), 16 (7%), and 11 (5%) patients, respectively. The sensitivity of CCE2 for polyps >= 6 mm, polyps >= 10 mm, and adenomas >= 10 mm was 79% (95% confidence interval (CI): 62-91%), 88% (95% CI: 62-98%), and 100% (95% CI: 72-100%), respectively. Conclusion. Second-generation capsule colonoscopy is a safe, noninvasive, and sensitive method for colorectal neoplasia detection although CC remains the preferred method for considerable proportion of subjects. CCE2 may therefore be accepted as the primary screening test for colorectal cancer screening.
Links
| NV16-29614A, research and development project |
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