| VONKOVÁ, Barbara, Ivona BLAHÁKOVÁ, Lukáš HRUBAN, Petr JANKŮ a Šárka POSPÍŠILOVÁ. MicroRNA-210 expression during childbirth and postpartum as a potential biomarker of acute fetal hypoxia. Biomedical Papers. Olomouc: Univerzita Palackého v Olomouci, 2019, roč. 163, č. 3, s. 259-264. ISSN 1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2018.075. |
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@article{1570958,
author = {Vonková, Barbara and Blaháková, Ivona and Hruban, Lukáš and Janků, Petr and Pospíšilová, Šárka},
article_location = {Olomouc},
article_number = {3},
doi = {http://dx.doi.org/10.5507/bp.2018.075},
keywords = {microRNA-210; acute fetal hypoxia; postpartum; clearance of miR-210},
language = {eng},
issn = {1213-8118},
journal = {Biomedical Papers},
title = {MicroRNA-210 expression during childbirth and postpartum as a potential biomarker of acute fetal hypoxia},
url = {https://biomed.papers.upol.cz/artkey/bio-201903-0011_microrna-210-expression-during-childbirth-and-postpartum-as-a-potential-biomarker-of-acute-fetal-hypoxia.php},
volume = {163},
year = {2019}
}
TY - JOUR
ID - 1570958
AU - Vonková, Barbara - Blaháková, Ivona - Hruban, Lukáš - Janků, Petr - Pospíšilová, Šárka
PY - 2019
TI - MicroRNA-210 expression during childbirth and postpartum as a potential biomarker of acute fetal hypoxia
JF - Biomedical Papers
VL - 163
IS - 3
SP - 259-264
EP - 259-264
PB - Univerzita Palackého v Olomouci
SN - 12138118
KW - microRNA-210
KW - acute fetal hypoxia
KW - postpartum
KW - clearance of miR-210
UR - https://biomed.papers.upol.cz/artkey/bio-201903-0011_microrna-210-expression-during-childbirth-and-postpartum-as-a-potential-biomarker-of-acute-fetal-hypoxia.php
L2 - https://biomed.papers.upol.cz/artkey/bio-201903-0011_microrna-210-expression-during-childbirth-and-postpartum-as-a-potential-biomarker-of-acute-fetal-hypoxia.php
N2 - Objective. To explore whether miR-210 expression can be used as a diagnostic and prognostic marker in acute fetal hypoxia. Methods. Whole blood samples of 29 women and their fetuses without hypoxia and 24 women and their fetuses with hypoxia were analysed in this study. Reverse transcription and quantitative real-time PCR were used to measure the expression of miR-210. Expression level differences between the control and hypoxic group in labour time and postpartum change fold were analyzed by standard statistical tests. Results. We confirmed that miR-210 is significantly more upregulated in fetal blood with acute hypoxia when compared to maternal blood (P<0.001). Furthermore, there was significant up-regulation in miR-210 level in the hypoxic group when compared to the control non-hypoxic group (P<0.05) in both maternal and fetal blood. Our results did not confirm a significant difference in postpartum miR-210 clearance level 2 h, 8 h, 24 h or 48 h after labour. Conclusions. Our study confirmed miR-210 upregulation in the blood of pregnant women with acute fetal hypoxia at the time of labour compared to pregnant women without acute fetal hypoxia. Additional investigation should be done to determine miR-210 clearance and the possibility of using miR-210 as a diagnostic and prognostic marker.
ER -
VONKOVÁ, Barbara, Ivona BLAHÁKOVÁ, Lukáš HRUBAN, Petr JANKŮ a Šárka POSPÍŠILOVÁ. MicroRNA-210 expression during childbirth and postpartum as a potential biomarker of acute fetal hypoxia. \textit{Biomedical Papers}. Olomouc: Univerzita Palackého v Olomouci, 2019, roč.~163, č.~3, s.~259-264. ISSN~1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2018.075.
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