| JAROŠOVÁ, Marie, Karla PLEVOVÁ, Jana KOTAŠKOVÁ, Michael DOUBEK a Šárka POSPÍŠILOVÁ. The importance of complex karyotype in prognostication and treatment of chronic lymphocytic leukemia (CLL): a comprehensive review of the literature. LEUKEMIA & LYMPHOMA. LONDON: INFORMA HEALTHCARE, roč. 60, č. 10, s. 2348-2355. ISSN 1042-8194. doi:10.1080/10428194.2019.1576038. 2019. |
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@article{1574782,
author = {Jarošová, Marie and Plevová, Karla and Kotašková, Jana and Doubek, Michael and Pospíšilová, Šárka},
article_location = {LONDON},
article_number = {10},
doi = {http://dx.doi.org/10.1080/10428194.2019.1576038},
keywords = {chromosomal aberrations; CLL; complex karyotype; FISH},
language = {eng},
issn = {1042-8194},
journal = {LEUKEMIA & LYMPHOMA},
title = {The importance of complex karyotype in prognostication and treatment of chronic lymphocytic leukemia (CLL): a comprehensive review of the literature},
url = {https://www.tandfonline.com/doi/full/10.1080/10428194.2019.1576038},
volume = {60},
year = {2019}
}
TY - JOUR
ID - 1574782
AU - Jarošová, Marie - Plevová, Karla - Kotašková, Jana - Doubek, Michael - Pospíšilová, Šárka
PY - 2019
TI - The importance of complex karyotype in prognostication and treatment of chronic lymphocytic leukemia (CLL): a comprehensive review of the literature
JF - LEUKEMIA & LYMPHOMA
VL - 60
IS - 10
SP - 2348-2355
EP - 2348-2355
PB - INFORMA HEALTHCARE
SN - 10428194
KW - chromosomal aberrations
KW - CLL
KW - complex karyotype
KW - FISH
UR - https://www.tandfonline.com/doi/full/10.1080/10428194.2019.1576038
L2 - https://www.tandfonline.com/doi/full/10.1080/10428194.2019.1576038
N2 - Cytogenetic examination and the detection of chromosomal aberrations in chronic lymphocytic leukemia (CLL) is an integral part of prognostic stratification and treatment decisions. Improvements in cytogenetic methods, notably the introduction of the cell stimulation method, have led to the detection of chromosomal aberrations in 80% of CLL cases. A comprehensive analysis of cytogenetic aberrations recently showed that complex karyotypes (CKs) defined as the detection of either three or more or five or more chromosomal changes in a karyotype have a poor prognostic impact. The current efforts at the international level are focused on the goal of including CK assessment among prognostic markers for CLL patients at diagnosis as well as after treatment. This review of the literature documents the clinical importance of CK findings in CLL and the necessity of including this factor in other poor prognostic indicators.
ER -
JAROŠOVÁ, Marie, Karla PLEVOVÁ, Jana KOTAŠKOVÁ, Michael DOUBEK a Šárka POSPÍŠILOVÁ. The importance of complex karyotype in prognostication and treatment of chronic lymphocytic leukemia (CLL): a comprehensive review of the literature. \textit{LEUKEMIA \&{}amp; LYMPHOMA}. LONDON: INFORMA HEALTHCARE, roč.~60, č.~10, s.~2348-2355. ISSN~1042-8194. doi:10.1080/10428194.2019.1576038. 2019.
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