The importance of complex karyotype in prognostication and
treatment of chronic lymphocytic leukemia (CLL): a
comprehensive review of the literature

J 2019

The importance of complex karyotype in prognostication and treatment of chronic lymphocytic leukemia (CLL): a comprehensive review of the literature

JAROŠOVÁ, Marie, Karla PLEVOVÁ, Jana KOTAŠKOVÁ, Michael DOUBEK, Šárka POSPÍŠILOVÁ et. al.

Basic information

Original name

The importance of complex karyotype in prognostication and treatment of chronic lymphocytic leukemia (CLL): a comprehensive review of the literature

Authors

JAROŠOVÁ, Marie (203 Czech Republic, belonging to the institution), Karla PLEVOVÁ (203 Czech Republic, belonging to the institution), Jana KOTAŠKOVÁ (203 Czech Republic, belonging to the institution), Michael DOUBEK (203 Czech Republic, belonging to the institution) and Šárka POSPÍŠILOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

LEUKEMIA & LYMPHOMA, LONDON, INFORMA HEALTHCARE, 2019, 1042-8194

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30205 Hematology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.969

RIV identification code

RIV/00216224:14740/19:00111112

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1080/10428194.2019.1576038

UT WoS

000489795900004

Keywords in English

chromosomal aberrations; CLL; complex karyotype; FISH

Abstract

V originále

Cytogenetic examination and the detection of chromosomal aberrations in chronic lymphocytic leukemia (CLL) is an integral part of prognostic stratification and treatment decisions. Improvements in cytogenetic methods, notably the introduction of the cell stimulation method, have led to the detection of chromosomal aberrations in 80% of CLL cases. A comprehensive analysis of cytogenetic aberrations recently showed that complex karyotypes (CKs) defined as the detection of either three or more or five or more chromosomal changes in a karyotype have a poor prognostic impact. The current efforts at the international level are focused on the goal of including CK assessment among prognostic markers for CLL patients at diagnosis as well as after treatment. This review of the literature documents the clinical importance of CK findings in CLL and the necessity of including this factor in other poor prognostic indicators.

Citovat

JAROŠOVÁ, Marie, Karla PLEVOVÁ, Jana KOTAŠKOVÁ, Michael DOUBEK and Šárka POSPÍŠILOVÁ. The importance of complex karyotype in prognostication and treatment of chronic lymphocytic leukemia (CLL): a comprehensive review of the literature. LEUKEMIA & LYMPHOMA. LONDON: INFORMA HEALTHCARE, 2019, vol. 60, No 10, p. 2348-2355. ISSN 1042-8194. Available from: https://dx.doi.org/10.1080/10428194.2019.1576038.

@article{1574782,
   author = {Jarošová, Marie and Plevová, Karla and Kotašková, Jana and Doubek, Michael and Pospíšilová, Šárka},
   article_location = {LONDON},
   article_number = {10},
   doi = {http://dx.doi.org/10.1080/10428194.2019.1576038},
   keywords = {chromosomal aberrations; CLL; complex karyotype; FISH},
   language = {eng},
   issn = {1042-8194},
   journal = {LEUKEMIA & LYMPHOMA},
   title = {The importance of complex karyotype in prognostication and treatment of chronic lymphocytic leukemia (CLL): a comprehensive review of the literature},
   url = {https://www.tandfonline.com/doi/full/10.1080/10428194.2019.1576038},
   volume = {60},
   year = {2019}
}

TY  - JOUR
ID  - 1574782
AU  - Jarošová, Marie - Plevová, Karla - Kotašková, Jana - Doubek, Michael - Pospíšilová, Šárka
PY  - 2019
TI  - The importance of complex karyotype in prognostication and treatment of chronic lymphocytic leukemia (CLL): a comprehensive review of the literature
JF  - LEUKEMIA & LYMPHOMA
VL  - 60
IS  - 10
SP  - 2348-2355
EP  - 2348-2355
PB  - INFORMA HEALTHCARE
SN  - 10428194
KW  - chromosomal aberrations
KW  - CLL
KW  - complex karyotype
KW  - FISH
UR  - https://www.tandfonline.com/doi/full/10.1080/10428194.2019.1576038
L2  - https://www.tandfonline.com/doi/full/10.1080/10428194.2019.1576038
N2  - Cytogenetic examination and the detection of chromosomal aberrations in chronic lymphocytic leukemia (CLL) is an integral part of prognostic stratification and treatment decisions. Improvements in cytogenetic methods, notably the introduction of the cell stimulation method, have led to the detection of chromosomal aberrations in 80% of CLL cases. A comprehensive analysis of cytogenetic aberrations recently showed that complex karyotypes (CKs) defined as the detection of either three or more or five or more chromosomal changes in a karyotype have a poor prognostic impact. The current efforts at the international level are focused on the goal of including CK assessment among prognostic markers for CLL patients at diagnosis as well as after treatment. This review of the literature documents the clinical importance of CK findings in CLL and the necessity of including this factor in other poor prognostic indicators.
ER  -

JAROŠOVÁ, Marie, Karla PLEVOVÁ, Jana KOTAŠKOVÁ, Michael DOUBEK and Šárka POSPÍŠILOVÁ. The importance of complex karyotype in prognostication and treatment of chronic lymphocytic leukemia (CLL): a comprehensive review of the literature. \textit{LEUKEMIA \&{}amp; LYMPHOMA}. LONDON: INFORMA HEALTHCARE, 2019, vol.~60, No~10, p.~2348-2355. ISSN~1042-8194. Available from: https://dx.doi.org/10.1080/10428194.2019.1576038.

Detailed Information on Publication Record