The importance of complex karyotype in prognostication and treatment of chronic lymphocytic leukemia (CLL): a comprehensive review of the literature

JAROŠOVÁ, Marie, Karla PLEVOVÁ, Jana KOTAŠKOVÁ, Michael DOUBEK and Šárka POSPÍŠILOVÁ. The importance of complex karyotype in prognostication and treatment of chronic lymphocytic leukemia (CLL): a comprehensive review of the literature. LEUKEMIA & LYMPHOMA. LONDON: INFORMA HEALTHCARE, 2019, vol. 60, No 10, p. 2348-2355. ISSN 1042-8194. Available from: https://dx.doi.org/10.1080/10428194.2019.1576038.

Basic information

• Original name: The importance of complex karyotype in prognostication and treatment of chronic lymphocytic leukemia (CLL): a comprehensive review of the literature
• Authors: JAROŠOVÁ, Marie (203 Czech Republic, belonging to the institution), Karla PLEVOVÁ (203 Czech Republic, belonging to the institution), Jana KOTAŠKOVÁ (203 Czech Republic, belonging to the institution), Michael DOUBEK (203 Czech Republic, belonging to the institution) and Šárka POSPÍŠILOVÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: LEUKEMIA & LYMPHOMA, LONDON, INFORMA HEALTHCARE, 2019, 1042-8194.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30205 Hematology
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 2.969
• RIV identification code: RIV/00216224:14740/19:00111112
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1080/10428194.2019.1576038
• UT WoS: 000489795900004
• Keywords in English: chromosomal aberrations; CLL; complex karyotype; FISH
• Tags: 14110212, podil, rivok
• Tags: International impact, Reviewed

Abstract

Cytogenetic examination and the detection of chromosomal aberrations in chronic lymphocytic leukemia (CLL) is an integral part of prognostic stratification and treatment decisions. Improvements in cytogenetic methods, notably the introduction of the cell stimulation method, have led to the detection of chromosomal aberrations in 80% of CLL cases. A comprehensive analysis of cytogenetic aberrations recently showed that complex karyotypes (CKs) defined as the detection of either three or more or five or more chromosomal changes in a karyotype have a poor prognostic impact. The current efforts at the international level are focused on the goal of including CK assessment among prognostic markers for CLL patients at diagnosis as well as after treatment. This review of the literature documents the clinical importance of CK findings in CLL and the necessity of including this factor in other poor prognostic indicators.