JURKOVIČOVÁ, Lenka, Robert ROMAN, Jan CIMBÁLNÍK, Radek MAREČEK and Milan BRÁZDIL. Cortical excitability and visual discomfort in epilepsy: SEEG study. In 66. český a slovenský sjezd klinické neurofyziologie. 2019.
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Basic information
Original name Cortical excitability and visual discomfort in epilepsy: SEEG study
Name in Czech Kortikální excitabilita a vizuální diskomfort u epilepsie: SEEG studie
Authors JURKOVIČOVÁ, Lenka, Robert ROMAN, Jan CIMBÁLNÍK, Radek MAREČEK and Milan BRÁZDIL.
Edition 66. český a slovenský sjezd klinické neurofyziologie, 2019.
Other information
Original language English
Type of outcome Conference abstract
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
Organization unit Faculty of Medicine
Keywords (in Czech) hyperexcitabilita, intrakraniální EEG, vysokofrekvenční oscilace, pattern glare
Keywords in English hyperexcitability, intracranial EEG, high-frequency oscillations, pattern glare
Tags International impact, Reviewed
Changed by Changed by: Mgr. Lenka Jurkovičová, učo 376213. Changed: 1/11/2019 23:59.
Abstract
Cortical excitability (CE) is defined as the strength of the response of cortical neurons to a given stimulation. Increased level of CE is a key neurophysiological mechanism in several neurological disorders, including epilepsy.Studies proved the existence of a relationship between increased CE and subjective visual discomfort during presentation of striped patterns of spatial frequency of approx. 3 cycles / degree, i.e. a pattern glare phenomenon. Individuals with increased CE, e.g. migraine patients, experience significantly higher frequency of visual distortions in comparison with healthy subjects. The study aims to examine intracranial electrophysiological correlates of the pattern glare during visual presentation of striped stimuli with spatial frequency of 0.5, 3 and 11 cpd. Eleven patients with pharmacoresistant epilepsy with depth electrodes implanted to localize seizure origin agreed to participate in the study. Subjective evaluation of stimuli was correlated with intracranial EEG record. High frequency oscillations (HFOs), power spectral analysis and connectivity patterns in 55­-80 Hz, 80­-250 Hz, 250­-600 Hz and 600­-1000 Hz frequency bands were analysed. Higher occurrence of HFOs, increased connectivity and mean EEG power mainly in the 80­-250 Hz frequency band in anterior and posterior hippocampi, anterior insula and precuneus were observed during the presentation of the subjectively most irritable stimuli. Our results point to possible electrophysiological correlates of increased cortical excitability related to perception of irritable stimuli during pattern glare task in epileptic patients.
Links
MUNI/A/1496/2018, interní kód MUName: Neurální koreláty paměťových a kognitivních funkcí u zdravé populace a neurologických pacientů
Investor: Masaryk University, Category A
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