a 2019

Inappropriate conversion of current magnitude to current density may misinterpret results

KULA, Roman, Markéta BÉBAROVÁ, Jiří ŠIMURDA and Michal PÁSEK

Basic information

Original name

Inappropriate conversion of current magnitude to current density may misinterpret results

Authors

KULA, Roman (203 Czech Republic, belonging to the institution), Markéta BÉBAROVÁ (203 Czech Republic, guarantor, belonging to the institution), Jiří ŠIMURDA (203 Czech Republic, belonging to the institution) and Michal PÁSEK (203 Czech Republic)

Edition

43rd EWGCCE Meeting, 2019

Other information

Language

English

Type of outcome

Conference abstract

Field of Study

30105 Physiology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

is not subject to a state or trade secret

References:

RIV identification code

RIV/00216224:14110/19:00108532

Organization unit

Faculty of Medicine

ISSN

Keywords in English

current amplitude; current density; capacitance; correlation; normalization

Tags

Tags

International impact, Reviewed
Changed: 22/4/2020 09:03, Mgr. Tereza Miškechová

Abstract

V originále

The magnitude of ionic current (I, in pA) is usually assumed to increase proportionally to the membrane area roughly estimated by measurement of the membrane capacitance (C, in pF). Hence, to lower differences of data measured in cells with varying cell membrane areas, the current density (J, in pA/pF) is routinely calculated as I/C ratio. However, if the I-C correlation was weak and insignificant, the conversion to J would be inappropriate and, if performed, could considerably change the interpretation of results.

Links

NV16-30571A, research and development project
Name: Klinický význam a elektrofyziologické zhodnocení mutace c.926C>T genu KCNQ1 (p.T309I) jako možné „founder mutation“ syndromu dlouhého intervalu QT