KULA, Roman, Markéta BÉBAROVÁ, Jiří ŠIMURDA and Michal PÁSEK. Inappropriate conversion of current magnitude to current density may misinterpret results. In 43rd EWGCCE Meeting. 2019. ISSN 1532-2092.
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Basic information
Original name Inappropriate conversion of current magnitude to current density may misinterpret results
Authors KULA, Roman (203 Czech Republic, belonging to the institution), Markéta BÉBAROVÁ (203 Czech Republic, guarantor, belonging to the institution), Jiří ŠIMURDA (203 Czech Republic, belonging to the institution) and Michal PÁSEK (203 Czech Republic).
Edition 43rd EWGCCE Meeting, 2019.
Other information
Original language English
Type of outcome Conference abstract
Field of Study 30105 Physiology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 4.045
RIV identification code RIV/00216224:14110/19:00108532
Organization unit Faculty of Medicine
ISSN 1532-2092
Keywords in English current amplitude; current density; capacitance; correlation; normalization
Tags rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 22/4/2020 09:03.
Abstract
The magnitude of ionic current (I, in pA) is usually assumed to increase proportionally to the membrane area roughly estimated by measurement of the membrane capacitance (C, in pF). Hence, to lower differences of data measured in cells with varying cell membrane areas, the current density (J, in pA/pF) is routinely calculated as I/C ratio. However, if the I-C correlation was weak and insignificant, the conversion to J would be inappropriate and, if performed, could considerably change the interpretation of results.
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NV16-30571A, research and development projectName: Klinický význam a elektrofyziologické zhodnocení mutace c.926C>T genu KCNQ1 (p.T309I) jako možné „founder mutation“ syndromu dlouhého intervalu QT
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