Unexpected therapeutic effects of cisplatin

J 2019

Unexpected therapeutic effects of cisplatin

RAUDENSKÁ, Martina, Jan BALVAN, Michaela FOJTŮ, Jaromír GUMULEC, Michal MASAŘÍK et. al.

Basic information

Original name

Unexpected therapeutic effects of cisplatin

Authors

RAUDENSKÁ, Martina (203 Czech Republic, belonging to the institution), Jan BALVAN (203 Czech Republic, belonging to the institution), Michaela FOJTŮ (203 Czech Republic, belonging to the institution), Jaromír GUMULEC (203 Czech Republic, belonging to the institution) and Michal MASAŘÍK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Metallomics, Cambridge, ROYAL SOC CHEMISTRY, 2019, 1756-5901

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.796

RIV identification code

RIV/00216224:14110/19:00107805

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1039/c9mt00049f

UT WoS

000475799400011

Keywords in English

VALOSIN-CONTAINING PROTEIN; SENSITIVE CHLORIDE CHANNELS; ENDOPLASMIC-RETICULUM STRESS; ANTICANCER DRUG CISPLATIN; COPPER TRANSPORTER CTR1; TUMOR-NECROSIS-FACTOR; NONMUSCLE MYOSIN IIA; BREAST-CANCER CELLS; MHC CLASS-I; INTRACELLULAR PH

Abstract

V originále

Cisplatin is a widely used chemotherapeutic agent that is clinically approved to fight both carcinomas and sarcomas. It has relatively high efficiency in treating ovarian cancers and metastatic testicular cancers. It is generally accepted that the major mechanism of cisplatin anti-cancer action is DNA damage. However, cisplatin is also effective in metastatic cancers and should, therefore, affect slow-cycling cancer stem cells in some way. In this review, we focused on the alternative effects of cisplatin that can support a good therapeutic response. First, attention was paid to the effects of cisplatin at the cellular level such as changes in intracellular pH and cellular mechanical properties. Alternative cellular targets of cisplatin, and the effects of cisplatin on cancer cell metabolism and ER stress were also discussed. Furthermore, the impacts of cisplatin on the tumor microenvironment and in the whole organism context were reviewed. In this review, we try to reveal possible causes of the unexpected effectiveness of this anti-cancer drug.

Links

GA18-03978S, research and development project

Name: Efekt buněčné tuhosti a mikroprostředí jako prediktor odpovědi na léčbu karcinomů hlavy a krku

Investor: Czech Science Foundation

NV18-08-00229, research and development project

Name: Interakce buněk nádorového mikroprostředí jako nový nástroj predikce účinnosti terapie nádorů hlavy a krku

Investor: Ministry of Health of the CR

ROZV/24/LF/2018, interní kód MU

Name: LF - Příspěvek na IP 2108

Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects

Citovat

RAUDENSKÁ, Martina, Jan BALVAN, Michaela FOJTŮ, Jaromír GUMULEC and Michal MASAŘÍK. Unexpected therapeutic effects of cisplatin. Metallomics. Cambridge: ROYAL SOC CHEMISTRY, 2019, vol. 11, No 7, p. 1182-1199. ISSN 1756-5901. Available from: https://dx.doi.org/10.1039/c9mt00049f.

@article{1582296,
   author = {Raudenská, Martina and Balvan, Jan and Fojtů, Michaela and Gumulec, Jaromír and Masařík, Michal},
   article_location = {Cambridge},
   article_number = {7},
   doi = {http://dx.doi.org/10.1039/c9mt00049f},
   keywords = {VALOSIN-CONTAINING PROTEIN; SENSITIVE CHLORIDE CHANNELS; ENDOPLASMIC-RETICULUM STRESS; ANTICANCER DRUG CISPLATIN; COPPER TRANSPORTER CTR1; TUMOR-NECROSIS-FACTOR; NONMUSCLE MYOSIN IIA; BREAST-CANCER CELLS; MHC CLASS-I; INTRACELLULAR PH},
   language = {eng},
   issn = {1756-5901},
   journal = {Metallomics},
   title = {Unexpected therapeutic effects of cisplatin},
   url = {http://dx.doi.org/10.1039/c9mt00049f},
   volume = {11},
   year = {2019}
}

TY  - JOUR
ID  - 1582296
AU  - Raudenská, Martina - Balvan, Jan - Fojtů, Michaela - Gumulec, Jaromír - Masařík, Michal
PY  - 2019
TI  - Unexpected therapeutic effects of cisplatin
JF  - Metallomics
VL  - 11
IS  - 7
SP  - 1182-1199
EP  - 1182-1199
PB  - ROYAL SOC CHEMISTRY
SN  - 17565901
KW  - VALOSIN-CONTAINING PROTEIN
KW  - SENSITIVE CHLORIDE CHANNELS
KW  - ENDOPLASMIC-RETICULUM STRESS
KW  - ANTICANCER DRUG CISPLATIN
KW  - COPPER TRANSPORTER CTR1
KW  - TUMOR-NECROSIS-FACTOR
KW  - NONMUSCLE MYOSIN IIA
KW  - BREAST-CANCER CELLS
KW  - MHC CLASS-I
KW  - INTRACELLULAR PH
UR  - http://dx.doi.org/10.1039/c9mt00049f
L2  - http://dx.doi.org/10.1039/c9mt00049f
N2  - Cisplatin is a widely used chemotherapeutic agent that is clinically approved to fight both carcinomas and sarcomas. It has relatively high efficiency in treating ovarian cancers and metastatic testicular cancers. It is generally accepted that the major mechanism of cisplatin anti-cancer action is DNA damage. However, cisplatin is also effective in metastatic cancers and should, therefore, affect slow-cycling cancer stem cells in some way. In this review, we focused on the alternative effects of cisplatin that can support a good therapeutic response. First, attention was paid to the effects of cisplatin at the cellular level such as changes in intracellular pH and cellular mechanical properties. Alternative cellular targets of cisplatin, and the effects of cisplatin on cancer cell metabolism and ER stress were also discussed. Furthermore, the impacts of cisplatin on the tumor microenvironment and in the whole organism context were reviewed. In this review, we try to reveal possible causes of the unexpected effectiveness of this anti-cancer drug.
ER  -

RAUDENSKÁ, Martina, Jan BALVAN, Michaela FOJTŮ, Jaromír GUMULEC and Michal MASAŘÍK. Unexpected therapeutic effects of cisplatin. \textit{Metallomics}. Cambridge: ROYAL SOC CHEMISTRY, 2019, vol.~11, No~7, p.~1182-1199. ISSN~1756-5901. Available from: https://dx.doi.org/10.1039/c9mt00049f.

Detailed Information on Publication Record