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@article{1582296,
author = {Raudenská, Martina and Balvan, Jan and Fojtů, Michaela and Gumulec, Jaromír and Masařík, Michal},
article_location = {Cambridge},
article_number = {7},
doi = {http://dx.doi.org/10.1039/c9mt00049f},
keywords = {VALOSIN-CONTAINING PROTEIN; SENSITIVE CHLORIDE CHANNELS; ENDOPLASMIC-RETICULUM STRESS; ANTICANCER DRUG CISPLATIN; COPPER TRANSPORTER CTR1; TUMOR-NECROSIS-FACTOR; NONMUSCLE MYOSIN IIA; BREAST-CANCER CELLS; MHC CLASS-I; INTRACELLULAR PH},
language = {eng},
issn = {1756-5901},
journal = {Metallomics},
title = {Unexpected therapeutic effects of cisplatin},
url = {http://dx.doi.org/10.1039/c9mt00049f},
volume = {11},
year = {2019}
}
TY - JOUR
ID - 1582296
AU - Raudenská, Martina - Balvan, Jan - Fojtů, Michaela - Gumulec, Jaromír - Masařík, Michal
PY - 2019
TI - Unexpected therapeutic effects of cisplatin
JF - Metallomics
VL - 11
IS - 7
SP - 1182-1199
EP - 1182-1199
PB - ROYAL SOC CHEMISTRY
SN - 17565901
KW - VALOSIN-CONTAINING PROTEIN
KW - SENSITIVE CHLORIDE CHANNELS
KW - ENDOPLASMIC-RETICULUM STRESS
KW - ANTICANCER DRUG CISPLATIN
KW - COPPER TRANSPORTER CTR1
KW - TUMOR-NECROSIS-FACTOR
KW - NONMUSCLE MYOSIN IIA
KW - BREAST-CANCER CELLS
KW - MHC CLASS-I
KW - INTRACELLULAR PH
UR - http://dx.doi.org/10.1039/c9mt00049f
L2 - http://dx.doi.org/10.1039/c9mt00049f
N2 - Cisplatin is a widely used chemotherapeutic agent that is clinically approved to fight both carcinomas and sarcomas. It has relatively high efficiency in treating ovarian cancers and metastatic testicular cancers. It is generally accepted that the major mechanism of cisplatin anti-cancer action is DNA damage. However, cisplatin is also effective in metastatic cancers and should, therefore, affect slow-cycling cancer stem cells in some way. In this review, we focused on the alternative effects of cisplatin that can support a good therapeutic response. First, attention was paid to the effects of cisplatin at the cellular level such as changes in intracellular pH and cellular mechanical properties. Alternative cellular targets of cisplatin, and the effects of cisplatin on cancer cell metabolism and ER stress were also discussed. Furthermore, the impacts of cisplatin on the tumor microenvironment and in the whole organism context were reviewed. In this review, we try to reveal possible causes of the unexpected effectiveness of this anti-cancer drug.
ER -
RAUDENSKÁ, Martina, Jan BALVAN, Michaela FOJTŮ, Jaromír GUMULEC and Michal MASAŘÍK. Unexpected therapeutic effects of cisplatin. \textit{Metallomics}. Cambridge: ROYAL SOC CHEMISTRY, 2019, vol.~11, No~7, p.~1182-1199. ISSN~1756-5901. Available from: https://dx.doi.org/10.1039/c9mt00049f.
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