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@article{1582296, author = {Raudenská, Martina and Balvan, Jan and Fojtů, Michaela and Gumulec, Jaromír and Masařík, Michal}, article_location = {Cambridge}, article_number = {7}, doi = {http://dx.doi.org/10.1039/c9mt00049f}, keywords = {VALOSIN-CONTAINING PROTEIN; SENSITIVE CHLORIDE CHANNELS; ENDOPLASMIC-RETICULUM STRESS; ANTICANCER DRUG CISPLATIN; COPPER TRANSPORTER CTR1; TUMOR-NECROSIS-FACTOR; NONMUSCLE MYOSIN IIA; BREAST-CANCER CELLS; MHC CLASS-I; INTRACELLULAR PH}, language = {eng}, issn = {1756-5901}, journal = {Metallomics}, title = {Unexpected therapeutic effects of cisplatin}, url = {http://dx.doi.org/10.1039/c9mt00049f}, volume = {11}, year = {2019} }
TY - JOUR ID - 1582296 AU - Raudenská, Martina - Balvan, Jan - Fojtů, Michaela - Gumulec, Jaromír - Masařík, Michal PY - 2019 TI - Unexpected therapeutic effects of cisplatin JF - Metallomics VL - 11 IS - 7 SP - 1182-1199 EP - 1182-1199 PB - ROYAL SOC CHEMISTRY SN - 17565901 KW - VALOSIN-CONTAINING PROTEIN KW - SENSITIVE CHLORIDE CHANNELS KW - ENDOPLASMIC-RETICULUM STRESS KW - ANTICANCER DRUG CISPLATIN KW - COPPER TRANSPORTER CTR1 KW - TUMOR-NECROSIS-FACTOR KW - NONMUSCLE MYOSIN IIA KW - BREAST-CANCER CELLS KW - MHC CLASS-I KW - INTRACELLULAR PH UR - http://dx.doi.org/10.1039/c9mt00049f L2 - http://dx.doi.org/10.1039/c9mt00049f N2 - Cisplatin is a widely used chemotherapeutic agent that is clinically approved to fight both carcinomas and sarcomas. It has relatively high efficiency in treating ovarian cancers and metastatic testicular cancers. It is generally accepted that the major mechanism of cisplatin anti-cancer action is DNA damage. However, cisplatin is also effective in metastatic cancers and should, therefore, affect slow-cycling cancer stem cells in some way. In this review, we focused on the alternative effects of cisplatin that can support a good therapeutic response. First, attention was paid to the effects of cisplatin at the cellular level such as changes in intracellular pH and cellular mechanical properties. Alternative cellular targets of cisplatin, and the effects of cisplatin on cancer cell metabolism and ER stress were also discussed. Furthermore, the impacts of cisplatin on the tumor microenvironment and in the whole organism context were reviewed. In this review, we try to reveal possible causes of the unexpected effectiveness of this anti-cancer drug. ER -
RAUDENSKÁ, Martina, Jan BALVAN, Michaela FOJTŮ, Jaromír GUMULEC and Michal MASAŘÍK. Unexpected therapeutic effects of cisplatin. \textit{Metallomics}. Cambridge: ROYAL SOC CHEMISTRY, 2019, vol.~11, No~7, p.~1182-1199. ISSN~1756-5901. Available from: https://dx.doi.org/10.1039/c9mt00049f.
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