Detailed Information on Publication Record
2019
Comparative structural analysis of lectin family from Photorhabdus spp.
HOUSER, Josef, Eva FUJDIAROVÁ, Gita JANČAŘÍKOVÁ, Filip MELICHER, Michaela WIMMEROVÁ et. al.Basic information
Original name
Comparative structural analysis of lectin family from Photorhabdus spp.
Authors
HOUSER, Josef (203 Czech Republic, belonging to the institution), Eva FUJDIAROVÁ (203 Czech Republic, belonging to the institution), Gita JANČAŘÍKOVÁ (203 Czech Republic, belonging to the institution), Filip MELICHER (703 Slovakia, belonging to the institution) and Michaela WIMMEROVÁ (203 Czech Republic, guarantor, belonging to the institution)
Edition
Instruct Ultra 3rd Structural biology meeting, 2019
Other information
Language
English
Type of outcome
Konferenční abstrakt
Field of Study
10608 Biochemistry and molecular biology
Country of publisher
Slovakia
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14740/19:00107830
Organization unit
Central European Institute of Technology
ISBN
978-80-971665-1-9
Keywords (in Czech)
lektiny; patogen; struktura; Photorhabdus
Keywords in English
lectins; pathogen; structure; Photorhabdus
Změněno: 3/12/2019 10:56, Mgr. Josef Houser, Ph.D.
Abstract
V originále
Photorhabdus is a genus of gram-negative bioluminescent bacteria living in a symbiosis with Heterorhabditis nematodes forming a highly entomopathogenic complex. Understanding the mechanisms that determine interaction between Photorhabdus and its symbionts/hosts could be highly beneficial not only in biotechnologies but also in clinical research and drug development. We analyzed several homologues of proteins PLL and PHL from Photorhabdus spp. We managed to prepare some of them in recombinant form and perform basic analysis, as well as solve structure of these proteins in free form and in complexes with naturally occurring saccharide ligands. This research may not only reveal the differences in similar proteins from one family, but also answer the question, why single species of bacteria possess the ability to produce several similar lectins.
Links
| GA13-25401S, research and development project |
| ||
| LM2015043, research and development project |
| ||
| LQ1601, research and development project |
|