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@proceedings{1587117,
author = {Houser, Josef and Fujdiarová, Eva and Jančaříková, Gita and Melicher, Filip and Wimmerová, Michaela},
booktitle = {Instruct Ultra 3rd Structural biology meeting},
keywords = {lectins; pathogen; structure; Photorhabdus},
language = {eng},
isbn = {978-80-971665-1-9},
title = {Comparative structural analysis of lectin family from Photorhabdus spp.},
year = {2019}
}
TY - CONF
ID - 1587117
AU - Houser, Josef - Fujdiarová, Eva - Jančaříková, Gita - Melicher, Filip - Wimmerová, Michaela
PY - 2019
TI - Comparative structural analysis of lectin family from Photorhabdus spp.
SN - 9788097166519
KW - lectins
KW - pathogen
KW - structure
KW - Photorhabdus
N2 - Photorhabdus is a genus of gram-negative bioluminescent bacteria living in a symbiosis with Heterorhabditis nematodes forming a highly entomopathogenic complex. Understanding the mechanisms that determine interaction between Photorhabdus and its symbionts/hosts could be highly beneficial not only in biotechnologies but also in clinical research and drug development. We analyzed several homologues of proteins PLL and PHL from Photorhabdus spp. We managed to prepare some of them in recombinant form and perform basic analysis, as well as solve structure of these proteins in free form and in complexes with naturally occurring saccharide ligands. This research may not only reveal the differences in similar proteins from one family, but also answer the question, why single species of bacteria possess the ability to produce several similar lectins.
ER -
HOUSER, Josef, Eva FUJDIAROVÁ, Gita JANČAŘÍKOVÁ, Filip MELICHER and Michaela WIMMEROVÁ. Comparative structural analysis of lectin family from Photorhabdus spp. In \textit{Instruct Ultra 3rd Structural biology meeting}. 2019. ISBN~978-80-971665-1-9.
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